CYTOKINE STRUCTURAL TAXONOMY AND MECHANISMS OF RECEPTOR ENGAGEMENT

被引：241

作者：

SPRANG, SR ^{[1
]}

BAZAN, JF ^{[1
]}

机构：

[1] DNAX RES INST MOLEC & CELLULAR BIOL INC, PALO ALTO, CA 94304 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1993年 / 3卷 / 06期

关键词：

D O I：

10.1016/0959-440X(93)90144-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Seven discrete families of cytokines have been identified by sequence and structural analysis. Within this diverse set of protein folds, the hematopoietic growth factors and tumor necrosis factor-like cytokines display a remarkable degree of variation upon their respective topological frameworks. In addition, prototype X-ray structures of ligand-receptor complexes reveal two different strategies of receptor engagement.

引用

页码：815 / 827

页数：13

共 96 条

[1] 3-DIMENSIONAL STRUCTURE OF A GENETICALLY ENGINEERED VARIANT OF PORCINE GROWTH-HORMONE [J].

ABDELMEGUID, SS ;

SHIEH, HS ;

SMITH, WW ;

DAYRINGER, HE ;

VIOLAND, BN ;

BENTLE, LA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (18) :6434-6437

[2] CRYSTAL-STRUCTURE OF BASIC FIBROBLAST GROWTH-FACTOR AT 1.6 A RESOLUTION [J].

AGO, H ;

KITAGAWA, Y ;

FUJISHIMA, A ;

MATSUURA, Y ;

KATSUBE, Y .

JOURNAL OF BIOCHEMISTRY, 1991, 110 (03) :360-363

[3] CYTOKINES - COORDINATORS OF IMMUNE AND INFLAMMATORY RESPONSES [J].

ARAI, K ;

LEE, F ;

MIYAJIMA, A ;

MIYATAKE, S ;

ARAI, N ;

YOKOTA, T .

ANNUAL REVIEW OF BIOCHEMISTRY, 1990, 59 :783-836

[4] MOLECULAR AND BIOLOGICAL CHARACTERIZATION OF A MURINE LIGAND FOR CD40 [J].

ARMITAGE, RJ ;

FANSLOW, WC ;

STROCKBINE, L ;

SATO, TA ;

CLIFFORD, KN ;

MACDUFF, BM ;

ANDERSON, DM ;

GIMPEL, SD ;

DAVISSMITH, T ;

MALISZEWSKI, CR ;

CLARK, EA ;

SMITH, CA ;

GRABSTEIN, KH ;

COSMAN, D ;

SPRIGGS, MK .

NATURE, 1992, 357 (6373) :80-82

[5] CRYSTAL-STRUCTURE OF INTERLEUKIN-8 - SYMBIOSIS OF NMR AND CRYSTALLOGRAPHY [J].

BALDWIN, ET ;

WEBER, IT ;

STCHARLES, R ;

XUAN, JC ;

APPELLA, E ;

YAMADA, M ;

MATSUSHIMA, K ;

EDWARDS, BFP ;

CLORE, GM ;

GRONENBORN, AM ;

WLODAWER, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (02) :502-506

[6] CRYSTAL-STRUCTURE OF THE SOLUBLE HUMAN 55 KD TNF RECEPTOR-HUMAN TNF-BETA COMPLEX - IMPLICATIONS FOR TNF RECEPTOR ACTIVATION [J].

BANNER, DW ;

DARCY, A ;

JANES, W ;

GENTZ, R ;

SCHOENFELD, HJ ;

BROGER, C ;

LOETSCHER, H ;

LESSLAUER, W .

CELL, 1993, 73 (03) :431-445

[7] EMERGING FAMILIES OF CYTOKINES AND RECEPTORS [J].

BAZAN, JF .

CURRENT BIOLOGY, 1993, 3 (09) :603-606

[8] NEUROPOIETIC CYTOKINES IN THE HEMATOPOIETIC FOLD [J].

BAZAN, JF .

NEURON, 1991, 7 (02) :197-208

[9] HEMATOPOIETIC RECEPTORS AND HELICAL CYTOKINES [J].

BAZAN, JF .

IMMUNOLOGY TODAY, 1990, 11 (10) :350-354

[10] STRUCTURAL DESIGN AND MOLECULAR EVOLUTION OF A CYTOKINE RECEPTOR SUPERFAMILY [J].

BAZAN, JF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (18) :6934-6938

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