Apoptosis and free radicals

被引：66

作者：

Stoian, I ^{[1
]}

Oros, A ^{[1
]}

Moldoveanu, E ^{[1
]}

机构：

[1] VICTOR BABES INST, R-76201 BUCHAREST, ROMANIA

来源：

BIOCHEMICAL AND MOLECULAR MEDICINE | 1996年 / 59卷 / 02期

关键词：

NF-KAPPA-B; SUPEROXIDE-DISMUTASE; OXIDATIVE STRESS; NITRIC-OXIDE; CELL-DEATH; ACTIVATION; ACETYLCYSTEINE; INHIBITION; MECHANISMS; INDUCTION;

D O I：

10.1006/bmme.1996.0072

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Free radicals that appear during physiological processes may lead to apoptosis in some pathological conditions when antioxidant capacity of the tissue is surpassed. Additionally, free radicals are involved in the control of apoptosis; antioxidant agents suppress apoptosis induced by a variety of stimuli. The possibility that apoptosis is regulated by modulation of the levels of free radicals is discussed. (C) 1996 Academic Press, Inc.

引用

收藏

页码：93 / 97

页数：5

相关论文

共 43 条

[31] DISTINCT EFFECTS OF THIOREDOXIN AND ANTIOXIDANTS ON THE ACTIVATION OF TRANSCRIPTION FACTORS NF-KAPPA-B AND AP-1 [J].

SCHENK, H ;

KLEIN, M ;

ERDBRUGGER, W ;

DROGE, W ;

SCHULZEOSTHOFF, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (05) :1672-1676

[32]

Schenk H, 1996, J IMMUNOL, V156, P765

[33] REACTIVE OXYGEN INTERMEDIATES AS APPARENTLY WIDELY USED MESSENGERS IN THE ACTIVATION OF THE NF-KAPPA-B TRANSCRIPTION FACTOR AND HIV-1 [J].

SCHRECK, R ;

RIEBER, P ;

BAEUERLE, PA .

EMBO JOURNAL, 1991, 10 (08) :2247-2258

[34] NITRONE SPIN TRAPS AND A NITROXIDE ANTIOXIDANT INHIBIT A COMMON PATHWAY OF THYMOCYTE APOPTOSIS [J].

SLATER, AFG ;

NOBEL, CSI ;

MAELLARO, E ;

BUSTAMANTE, J ;

KIMLAND, M ;

ORRENIUS, S .

BIOCHEMICAL JOURNAL, 1995, 306 :771-778

[35] APOPTOSIS INDUCED BY DNA TOPOISOMERASE-I AND TOPOISOMERASE-II INHIBITORS IN HUMAN LEUKEMIC HL-60 CELLS [J].

SOLARY, E ;

BERTRAND, R ;

POMMIER, Y .

LEUKEMIA & LYMPHOMA, 1994, 15 (1-2) :21-32

[36] MECHANISMS OF APOPTOSIS - INTEGRATION OF GENETIC, BIOCHEMICAL, AND CELLULAR INDICATORS [J].

STEWART, BW .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1994, 86 (17) :1286-1296

[37] NITRIC-OXIDE - A MACROPHAGE PRODUCT RESPONSIBLE FOR CYTOSTASIS AND RESPIRATORY INHIBITION IN TUMOR TARGET-CELLS [J].

STUEHR, DJ ;

NATHAN, CF .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (05) :1543-1555

[38] APOPTOSIS IN THE PATHOGENESIS AND TREATMENT OF DISEASE [J].

THOMPSON, CB .

SCIENCE, 1995, 267 (5203) :1456-1462

[39] INHIBITORS OF OXIDATIVE STRESS MIMIC THE ABILITY OF FOLLICLE-STIMULATING-HORMONE TO SUPPRESS APOPTOSIS IN CULTURED RAT OVARIAN FOLLICLES [J].

TILLY, JL ;

TILLY, KI .

ENDOCRINOLOGY, 1995, 136 (01) :242-252

[40] DOWN-REGULATION OF COPPER/ZINC SUPEROXIDE-DISMUTASE CAUSES APOPTOTIC DEATH IN PC12 NEURONAL CELLS [J].

TROY, CM ;

SHELANSKI, ML .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (14) :6384-6387

← 1 2 3 4 5 →