Interleukin-17C Promotes Th17 Cell Responses and Autoimmune Disease via Interleukin-17 Receptor E

被引：242

作者：

Chang, Seon Hee ^{[1
,2
]}

Reynolds, Joseph M. ^{[1
,2
]}

Pappu, Bhanu P. ^{[1
,2
]}

Chen, Guangjie ^{[1
,2
]}

Martinez, Gustavo J. ^{[1
,2
]}

Dong, Chen ^{[1
,2
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77054 USA

[2] Univ Texas MD Anderson Canc Ctr, Ctr Inflammat & Canc, Houston, TX 77054 USA

来源：

IMMUNITY | 2011年 / 35卷 / 04期

关键词：

T-CELLS; NUCLEAR RECEPTORS; FAMILY CYTOKINES; ADAPTER PROTEIN; HELPER-CELLS; ROR-GAMMA; DIFFERENTIATION; INFLAMMATION; GENERATION; T(H)17;

D O I：

10.1016/j.immuni.2011.09.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although several interleukin-17 (IL-17) family members and their receptors have been recently appreciated as important regulators in inflammatory diseases, the function of other IL-17 cytokines and IL-17 receptor-like molecules is unclear. Here we show that an IL-17 cytokine family member, IL-17C, was induced in a Th17 cell-dependent autoimmune disease and was required for its pathogenesis. IL-17C bound to IL-17RE, a member of IL-17 receptor family whose full-length isoform was selectively expressed in Th17 cells and signaled via an IL-17RA-RE receptor complex and the downstream adaptor Act1 IL-17C-IL-17RE induced the expression of a nuclear IkappaB family member, I kappa B zeta, in Th17 cells to potentiate the Th17 cell response. Thus, our work has identified a cytokine-receptor pair with important function in regulating proinflammatory responses. This pathway may be targeted to treat autoimmune diseases.

引用

页码：611 / 621

页数：11

共 40 条

[11] The immune gene repertoire encoded in the purple sea urchin genome [J].

Hibino, Taku ;

Loza-Coll, Mariano ;

Messier, Cynthia ;

Majeske, Audrey J. ;

Cohen, Avis H. ;

Terwilliger, David P. ;

Buckley, Katherine M. ;

Brockton, Virginia ;

Nair, Sham V. ;

Berney, Kevin ;

Fugmann, Sebastian D. ;

Anderson, Michele K. ;

Pancer, Zeev ;

Cameron, R. Andrew ;

Smith, L. Courtney ;

Rast, Jonathan P. .

DEVELOPMENTAL BIOLOGY, 2006, 300 (01) :349-365

[12] IL-17RC Is Required for IL-17A-and IL-17F-Dependent Signaling and the Pathogenesis of Experimental Autoimmune Encephalomyelitis [J].

Hu, Yan ;

Ota, Naruhisa ;

Peng, Ivan ;

Refino, Canio J. ;

Danilenko, Dimitry M. ;

Caplazi, Patrick ;

Ouyang, Wenjun .

JOURNAL OF IMMUNOLOGY, 2010, 184 (08) :4307-4316

[13] New IL-17 family members promote Th1 or Th2 responses in the lung: In vivo function of the novel cytokine IL-25 [J].

Hurst, SD ;

Muchamuel, T ;

Gorman, DM ;

Gilbert, JM ;

Clifford, T ;

Kwan, S ;

Menon, S ;

Seymour, B ;

Jackson, C ;

Kung, TT ;

Brieland, JK ;

Zurawski, SM ;

Chapman, RW ;

Zurawski, G ;

Coffman, RL .

JOURNAL OF IMMUNOLOGY, 2002, 169 (01) :443-453

[14] The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells [J].

Ivanov, Ivaylo I. ;

McKenzie, Brent S. ;

Zhou, Liang ;

Tadokoro, Carlos E. ;

Lepelley, Alice ;

Lafaille, Juan J. ;

Cua, Daniel J. ;

Littman, Dan R. .

CELL, 2006, 126 (06) :1121-1133

[15] Interleukin-17 family members and inflammation [J].

Kolls, JK ;

Lindén, A .

IMMUNITY, 2004, 21 (04) :467-476

[16] IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells [J].

Korn, Thomas ;

Bettelli, Estelle ;

Gao, Wenda ;

Awasthi, Amit ;

Jaeger, Anneli ;

Strom, Terry B. ;

Oukka, Mohamed ;

Kuchroo, Vijay K. .

NATURE, 2007, 448 (7152) :484-U9

[17] Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F [J].

Kuestner, Rolf E. ;

Taft, David W. ;

Haran, Aaron ;

Brandt, Cameron S. ;

Brender, Ty ;

Lum, Karen ;

Harder, Brandon ;

Okada, Shannon ;

Ostrander, Craig D. ;

Kreindler, James L. ;

Aujla, Shean J. ;

Reardon, Brian ;

Moore, Margaret ;

Shea, Pamela ;

Schreckhise, Randall ;

Bukowski, Thomas R. ;

Presnell, Scott ;

Guerra-Lewis, Patricia ;

Parrish-Novak, Julia ;

Ellsworth, Jeff L. ;

Jaspers, Stephen ;

Lewis, Katherine E. ;

Appleby, Mark ;

Kolls, Jay K. ;

Rixon, Mark ;

West, James W. ;

Gao, Zeren ;

Levin, Steven D. .

JOURNAL OF IMMUNOLOGY, 2007, 179 (08) :5462-5473

[18] IL-23 drives a pathogenic T cell population that induces autoimmune inflammation [J].

Langrish, CL ;

Chen, Y ;

Blumenschein, WM ;

Mattson, J ;

Basham, B ;

Sedgwick, JD ;

McClanahan, T ;

Kastelein, RA ;

Cua, DJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (02) :233-240

[19] Identification and functional characterization of a novel interleukin 17 receptor: A possible mitogenic activation through ras/mitogen-activated protein kinase signaling pathway [J].

Li, Tie-Shi ;

Li, Xue-Ni ;

Chang, Zhi-Jie ;

Fu, Xin-Yuan ;

Liu, Li .

CELLULAR SIGNALLING, 2006, 18 (08) :1287-1298

[20] Transforming growth factor-β induces development of the TH17 lineage [J].

Mangan, PR ;

Harrington, LE ;

O'Quinn, DB ;

Helms, WS ;

Bullard, DC ;

Elson, CO ;

Hatton, RD ;

Wahl, SM ;

Schoeb, TR ;

Weaver, CT .

NATURE, 2006, 441 (7090) :231-234

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