Interleukin-17 family members and inflammation

被引：2190

作者：

Kolls, JK ^{[1
]}

Lindén, A

机构：

[1] Childrens Hosp Pittsburgh, Dept Pediat, Div Pulm, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Pittsburgh, PA 15260 USA

[3] Sahlgrens Acad, Inst Internal Med, Dept Allergol & Resp Med, S-41345 Gothenburg, Sweden

[4] Univ Gothenburg, S-41345 Gothenburg, Sweden

来源：

IMMUNITY | 2004年 / 21卷 / 04期

关键词：

D O I：

10.1016/j.immuni.2004.08.018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IL-17A was cloned more than 10 years ago and six IL-17 family members (IL-17A-F) have subsequently been described. IL-17A is largely produced by activated memory T lymphocytes but stimulates innate immunity and host defense. IL-17A and IL-17F both mobilize neutrophils partly through granulopoeisis and CXC chemokine induction, as well as increased survival locally. IL-17A and IL-17F production by T lymphocytes is regulated by IL-23 independent of T cell receptor activation. Increasing evidence shows that IL-1 7 family members play an active role in inflammatory diseases, autoimmune diseases, and cancer. This places IL-17 family members and their receptors as potential targets for future pharmacotherapy.

引用

页码：467 / 476

页数：10

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