Small RNAs have a large impact Circulating microRNAs as biomarkers for human diseases

被引：228

作者：

Weiland, Matthew ^{[1
,2
]}

Gao, Xing-Hua ^{[3
]}

Zhou, Li ^{[1
,2
,4
]}

Mi, Qing-Sheng ^{[1
,2
,4
]}

机构：

[1] Henry Ford Hlth Syst, Henry Ford Immunol Program, Detroit, MI USA

[2] Henry Ford Hlth Syst, Dept Dermatol, Detroit, MI USA

[3] China Med Univ, Dept Dermatol, Hosp 1, Shenyang, Peoples R China

[4] Henry Ford Hlth Syst, Dept Internal Med, Detroit, MI USA

来源：

RNA BIOLOGY | 2012年 / 9卷 / 06期

关键词：

microRNA; circulating; biomarker; PLASMA MICRORNAS; CANCER-PATIENTS; SERUM; EXPRESSION; SIGNATURES; DIAGNOSIS; MARKERS; LEVEL; DICER; DNA;

D O I：

10.4161/rna.20378

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The highly conserved RNAs, microRNAs (miRNAs), are a class of small single stranded noncoding RNAs that function through translational repression of specific target mRNAs. miRNAs exhibit a wide range of involvement regulating gene expressions. miRNA expression dysregulated in cancer cells and damaged tissues from different diseases implicates a functional role of miRNAs in the disease development. More recently miRNAs have been detected in cell-free serum, and these circulating miRNAs can distinguish diseased individuals from healthy controls. The noninvasive nature of circulating miRNA collection and their sensitivity and specificity in diseases has encouraged a pursuit of miRNA biomarker research. As a result, approximately 100 circulating miRNAs have been identified as biomarkers for different diseases, and the number is growing. Here we review recently reported circulating miRNA biomarkers and discuss their values and challenges for the disease biomarkers.

引用

页码：850 / 859

页数：10

共 61 条

[31] miR-24 up-regulation in oral carcinoma: Positive association from clinical and in vitro analysis [J].

Lin, Shu-Chun ;

Liu, Chung-Ji ;

Lin, Jung-An ;

Chiang, Wei-Fan ;

Hung, Pei-Shih ;

Chang, Kuo-Wei .

ORAL ONCOLOGY, 2010, 46 (03) :204-208

[32] Increase of microRNA miR-31 level in plasma could be a potential marker of oral cancer [J].

Liu, C-J ;

Kao, S-Y ;

Tu, H-F ;

Tsai, M-M ;

Chang, K-W ;

Lin, S-C .

ORAL DISEASES, 2010, 16 (04) :360-364

[33] A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis [J].

Liu, Rui ;

Zhang, Chunni ;

Hu, Zhibin ;

Li, Gou ;

Wang, Cheng ;

Yang, Cuihua ;

Huang, Dingzhi ;

Chen, Xi ;

Zhang, Haiyang ;

Zhuang, Rui ;

Deng, Ting ;

Liu, Hua ;

Yin, Jingjing ;

Wang, Sufen ;

Zen, Ke ;

Ba, Yi ;

Zhang, Chen-Yu .

EUROPEAN JOURNAL OF CANCER, 2011, 47 (05) :784-791

[34]

Liu XG, 2011, MED ONCOL

[35] Detection of Cancer with Serum miRNAs on an Oligonucleotide Microarray [J].

Lodes, Michael J. ;

Caraballo, Marcelo ;

Suciu, Dominic ;

Munro, Sandra ;

Kumar, Amit ;

Anderson, Brooke .

PLOS ONE, 2009, 4 (07)

[36]

MANDEL P, 1948, CR SOC BIOL, V142, P241

[37] Circulating microRNAs as stable blood-based markers for cancer detection [J].

Mitchell, Patrick S. ;

Parkin, Rachael K. ;

Kroh, Evan M. ;

Fritz, Brian R. ;

Wyman, Stacia K. ;

Pogosova-Agadjanyan, Era L. ;

Peterson, Amelia ;

Noteboom, Jennifer ;

O'Briant, Kathy C. ;

Allen, April ;

Lin, Daniel W. ;

Urban, Nicole ;

Drescher, Charles W. ;

Knudsen, Beatrice S. ;

Stirewalt, Derek L. ;

Gentleman, Robert ;

Vessella, Robert L. ;

Nelson, Peter S. ;

Martin, Daniel B. ;

Tewari, Muneesh .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (30) :10513-10518

[38] Differential expression of microRNAs in plasma of patients with colorectal cancer: a potential marker for colorectal cancer screening [J].

Ng, E. K. O. ;

Chong, W. W. S. ;

Jin, H. ;

Lam, E. K. Y. ;

Shin, V. Y. ;

Yu, J. ;

Poon, T. C. W. ;

Ng, S. S. M. ;

Sung, J. J. Y. .

GUT, 2009, 58 (10) :1375-1381

[39] Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA [J].

Pasquinelli, AE ;

Reinhart, BJ ;

Slack, F ;

Martindale, MQ ;

Kuroda, MI ;

Maller, B ;

Hayward, DC ;

Ball, EE ;

Degnan, B ;

Müller, P ;

Spring, J ;

Srinivasan, A ;

Fishman, M ;

Finnerty, J ;

Corbo, J ;

Levine, M ;

Leahy, P ;

Davidson, E ;

Ruvkun, G .

NATURE, 2000, 408 (6808) :86-89

[40]

Qi R, 2011, HEPATOLOGY

← 1 2 3 4 5 6 7 →