Small RNAs have a large impact Circulating microRNAs as biomarkers for human diseases

被引：228

作者：

Weiland, Matthew ^{[1
,2
]}

Gao, Xing-Hua ^{[3
]}

Zhou, Li ^{[1
,2
,4
]}

Mi, Qing-Sheng ^{[1
,2
,4
]}

机构：

[1] Henry Ford Hlth Syst, Henry Ford Immunol Program, Detroit, MI USA

[2] Henry Ford Hlth Syst, Dept Dermatol, Detroit, MI USA

[3] China Med Univ, Dept Dermatol, Hosp 1, Shenyang, Peoples R China

[4] Henry Ford Hlth Syst, Dept Internal Med, Detroit, MI USA

来源：

RNA BIOLOGY | 2012年 / 9卷 / 06期

关键词：

microRNA; circulating; biomarker; PLASMA MICRORNAS; CANCER-PATIENTS; SERUM; EXPRESSION; SIGNATURES; DIAGNOSIS; MARKERS; LEVEL; DICER; DNA;

D O I：

10.4161/rna.20378

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The highly conserved RNAs, microRNAs (miRNAs), are a class of small single stranded noncoding RNAs that function through translational repression of specific target mRNAs. miRNAs exhibit a wide range of involvement regulating gene expressions. miRNA expression dysregulated in cancer cells and damaged tissues from different diseases implicates a functional role of miRNAs in the disease development. More recently miRNAs have been detected in cell-free serum, and these circulating miRNAs can distinguish diseased individuals from healthy controls. The noninvasive nature of circulating miRNA collection and their sensitivity and specificity in diseases has encouraged a pursuit of miRNA biomarker research. As a result, approximately 100 circulating miRNAs have been identified as biomarkers for different diseases, and the number is growing. Here we review recently reported circulating miRNA biomarkers and discuss their values and challenges for the disease biomarkers.

引用

页码：850 / 859

页数：10

共 61 条

[21] The circulating microRNA-221 level in patients with malignant melanoma as a new tumor marker [J].

Kanemaru, Hisashi ;

Fukushima, Satoshi ;

Yamashita, Junji ;

Honda, Noritoshi ;

Oyama, Rie ;

Kakimoto, Asako ;

Masuguchi, Shinichi ;

Ishihara, Tsuyoshi ;

Inoue, Yuji ;

Jinnin, Masatoshi ;

Ihn, Hironobu .

JOURNAL OF DERMATOLOGICAL SCIENCE, 2011, 61 (03) :187-193

[22] Circulating microRNAs in plasma of patients with oesophageal squamous cell carcinoma [J].

Komatsu, S. ;

Ichikawa, D. ;

Takeshita, H. ;

Tsujiura, M. ;

Morimura, R. ;

Nagata, H. ;

Kosuga, T. ;

Iitaka, D. ;

Konishi, H. ;

Shiozaki, A. ;

Fujiwara, H. ;

Okamoto, K. ;

Otsuji, E. .

BRITISH JOURNAL OF CANCER, 2011, 105 (01) :104-111

[23] Detection of Differentially Expressed microRNAs in Serum of Pancreatic Ductal Adenocarcinoma Patients: miR-196a Could Be a Potential Marker for Poor Prognosis [J].

Kong, Xiangyu ;

Du, Yiqi ;

Wang, Guokun ;

Gao, Jun ;

Gong, Yanfang ;

Li, Lei ;

Zhang, Zhuo ;

Zhu, Jiaqi ;

Jing, Qing ;

Qin, Yongwen ;

Li, Zhaoshen .

DIGESTIVE DISEASES AND SCIENCES, 2011, 56 (02) :602-609

[24] Plasma MicroRNAs as Sensitive and Specific Biomarkers of Tissue Injury [J].

Laterza, Omar F. ;

Lim, Lee ;

Garrett-Engele, Philip W. ;

Vlasakova, Katerina ;

Muniappa, Nagaraja ;

Tanaka, Wesley K. ;

Johnson, Jason M. ;

Sina, Joseph F. ;

Fare, Thomas L. ;

Sistare, Frank D. ;

Glaab, Warren E. .

CLINICAL CHEMISTRY, 2009, 55 (11) :1977-1983

[25] Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma [J].

Lawrie, Charles H. ;

Gal, Shira ;

Dunlop, Heather M. ;

Pushkaran, Beena ;

Liggins, Amanda P. ;

Pulford, Karen ;

Banham, Alison H. ;

Pezzella, Francesco ;

Boultwood, Jacqueline ;

Wainscoat, James S. ;

Hatton, Christian S. R. ;

Harris, Adrian L. .

BRITISH JOURNAL OF HAEMATOLOGY, 2008, 141 (05) :672-675

[26] THE C-ELEGANS HETEROCHRONIC GENE LIN-4 ENCODES SMALL RNAS WITH ANTISENSE COMPLEMENTARITY TO LIN-14 [J].

LEE, RC ;

FEINBAUM, RL ;

AMBROS, V .

CELL, 1993, 75 (05) :843-854

[27]

LEON SA, 1977, CANCER RES, V37, P646

[28] Circulating MicroRNAs as Potential Markers of Human Drug-Induced Liver Injury [J].

Lewis, Philip J. Starkey ;

Dear, James ;

Platt, Vivien ;

Simpson, Kenneth J. ;

Craig, Darren G. N. ;

Antoine, Daniel J. ;

French, Neil S. ;

Dhaun, Neeraj ;

Webb, David J. ;

Costello, Eithne M. ;

Neoptolemos, John P. ;

Moggs, Jonathan ;

Goldring, Chris E. ;

Park, B. Kevin .

HEPATOLOGY, 2011, 54 (05) :1767-1776

[29] Pancreatic Cancers Epigenetically Silence SIP1 and Hypomethylate and Overexpress miR-200a/200b in Association with Elevated Circulating miR-200a and miR-200b Levels [J].

Li, Ang ;

Omura, Noriyuki ;

Hong, Seung-Mo ;

Vincent, Audrey ;

Walter, Kimberly ;

Griffith, Margaret ;

Borges, Michael ;

Goggins, Michael .

CANCER RESEARCH, 2010, 70 (13) :5226-5237

[30] A special issue on DNA damage responses and genome maintenance [J].

Li, Guo-Min ;

Chen, David J. ;

Mitra, Sankar ;

Turchi, John J. .

CELL RESEARCH, 2008, 18 (01) :1-2

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