Saturation multipoint linkage mapping of chromosome 6q in type 1 diabetes

被引：59

作者：

Davies, JL ^{[1
]}

Cucca, F ^{[1
]}

Goy, JV ^{[1
]}

Atta, ZAA ^{[1
]}

Merriman, ME ^{[1
]}

Wilson, A ^{[1
]}

Barnett, AH ^{[1
]}

Bain, SC ^{[1
]}

Todd, JA ^{[1
]}

机构：

[1] UNIV BIRMINGHAM,BIRMINGHAM HEARTLANDS HOSP,DEPT MED DIABET ENDOCRINOL,BIRMINGHAM B9 5SS,W MIDLANDS,ENGLAND

来源：

HUMAN MOLECULAR GENETICS | 1996年 / 5卷 / 07期

基金：

英国惠康基金;

关键词：

D O I：

10.1093/hmg/5.7.1071

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Linkage analysis of type 1 diabetes sib pair families (n = 334) has suggested two separate regions of human chromosome 6q are linked to disease (designated IDDM5 and IDDM8), To test if these are false positive results, all available sib pair families (n = 429) were typed using a 92% informative map of chromosome 6q and multipoint analysis, The two regions still showed positive evidence of linkage, most notably the proterminal region, 6q27, corresponding to IDDM8 (MLS = 2.57, p = 0.0006; lambda(s) = 1.17). In addition, some evidence of transmission disequilibrium was seen with marker a046xa9 (IDDM5).

引用

页码：1071 / 1074

页数：4

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