THE 1993-94 GENETHON HUMAN GENETIC-LINKAGE MAP

被引：2128

作者：

GYAPAY, G

MORISSETTE, J

VIGNAL, A

DIB, C

FIZAMES, C

MILLASSEAU, P

MARC, S

BERNARDI, G

LATHROP, M

WEISSENBACH, J

机构：

[1] CTR ETUD POLYMORPHISME HUMAIN,F-75010 PARIS,FRANCE

[2] CHU LAVAL,RESEAU MED GENET,LAVAL,PQ,CANADA

[3] INST JACQUES MONOD,GENET MOLEC LAB,F-75005 PARIS,FRANCE

[4] INSERM,U358,F-75010 PARIS,FRANCE

[5] INST PASTEUR,UNITE GENET MOLEC HUMAINE,CNRS,URA 1445,F-75724 PARIS,FRANCE

来源：

NATURE GENETICS | 1994年 / 7卷 / 02期

关键词：

D O I：

10.1038/ng0694supp-246

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In 1992, we described a second-generation genetic linkage map of the human genome. Using 1,267 new microsatellite markers, we now present a new genetic linkage map containing a total of 2,066 (AC)(n) short tandem repeats, 60% of which show a heterozygosity of over 0.7. Statistical linkage analysis based on the genotyping of eight large CEPH families placed these markers in the 23 linkage groups. The map includes 1,266 intervals and spans a total distance of 3690 centiMorgans (cM). A total of 1,041 markers could be ordered with odds ratios greater that 1000:1. About 56% of this map is at a distance of 1 cM or less from one of its markers.

引用

页码：246 / 339

页数：94

共 32 条

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