Conservation anchors in the vertebrate genome

被引：6

作者：

Aloni, R

Lancet, D ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel

[2] Weizmann Inst Sci, Crown Human Genome Ctr, IL-76100 Rehovot, Israel

来源：

GENOME BIOLOGY | 2005年 / 6卷 / 07期

关键词：

D O I：

10.1186/gb-2005-6-7-115

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Genomic segments that do not code for proteins yet show high conservation among vertebrates have recently been identified by various computational methodologies. We refer to them as ANCORs (ancestral non-coding conserved regions). The frequency of individual ANCORs within the genome, along with their (correlated) inter-species identity scores, helps in assessing the probability that they function in transcription regulation or RNA coding.

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