Evolutionary discrimination of mammalian conserved non-genic sequences (CNGs)

被引：148

作者：

Dermitzakis, ET ^{[1
]}

Reymond, A

Scamuffa, N

Ucla, C

Kirkness, E

Rossier, C

Antonarakis, SE

机构：

[1] Univ Geneva, Sch Med, Div Med Genet, CH-1211 Geneva, Switzerland

[2] Univ Geneva, Sch Med, Natl Ctr Competence Res Frontiers Genet, CH-1211 Geneva, Switzerland

[3] Univ Hosp, CH-1211 Geneva, Switzerland

[4] TIGR, Rockville, MD 20850 USA

来源：

SCIENCE | 2003年 / 302卷 / 5647期

关键词：

D O I：

10.1126/science.1087047

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Analysis of the human and mouse genomes identified an abundance of conserved non-genic sequences (CNGs). The significance and evolutionary depth of their conservation remain unanswered. We have quantified levels and patterns of conservation of 191 CNGs of human chromosome 21 in 14 mammalian species. We found that CNGs are significantly more conserved than protein-coding genes and noncoding RNAS (ncRNAs) within the mammalian class from primates to monotremes to marsupials. The pattern of substitutions in CNGs differed from that seen in protein-coding and ncRNA genes and resembled that of protein-binding regions. About 0.3% to 1% of the human genome corresponds to a previously unknown class of extremely constrained CNGs shared among mammals.

引用

页码：1033 / 1035

页数：3

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