Active conservation of noncoding sequences revealed by three-way species comparisons

被引：270

作者：

Dubchak, I

Brudno, M

Loots, GG

Pachter, L

Mayor, C

Rubin, EM

Frazer, KA ^{[1
]}

机构：

[1] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Genome Sci Dept, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Ctr Bioinformat & Computat Genom, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Dept Math, Berkeley, CA 94720 USA

来源：

GENOME RESEARCH | 2000年 / 10卷 / 09期

关键词：

D O I：

10.1101/gr.142200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human and mouse genomic sequence comparisons are being increasingly used to search for evolutionarily conserved gene regulatory elements. Large-scale human-mouse DNA comparison studies have discovered numerous conserved noncoding sequences of which only a fraction has been functionally investigated A question therefore remains as to whether most of these noncoding sequences are conserved because of functional constraints or are the result of a lack of divergence time.

引用

页码：1304 / 1306

页数：3

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