Molecular architecture of the kinetochore-microtubule interface

被引：722

作者：

Cheeseman, Iain M. ^{[1
,2
]}

Desai, Arshad ^{[3
,4
]}

机构：

[1] MIT, Whitehead Inst Biomed Res, Nine Cambridge Ctr, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, Nine Cambridge Ctr, Cambridge, MA 02142 USA

[3] Univ Calif San Diego, CMM E, Ludwig Inst Canc Res, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, CMM E, Dept Cellular & Mol Med, La Jolla, CA 92093 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2008年 / 9卷 / 01期

关键词：

D O I：

10.1038/nrm2310

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Segregation of the replicated genome during cell division in eukaryotes requires the kinetochore to link centromeric DNA to spindle microtubules. The kinetochore is composed of a number of conserved protein complexes that direct its specification and assembly, bind to spindle microtubules and regulate chromosome segregation. Recent studies have identified more than 80 kinetochore components, and are revealing how these proteins are organized into the higher order kinetochore structure, as well as how they function to achieve proper chromosome segregation.

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页码：33 / 46

页数：14

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