Molecular architecture of the kinetochore-microtubule interface

被引：722

作者：

Cheeseman, Iain M. ^{[1
,2
]}

Desai, Arshad ^{[3
,4
]}

机构：

[1] MIT, Whitehead Inst Biomed Res, Nine Cambridge Ctr, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, Nine Cambridge Ctr, Cambridge, MA 02142 USA

[3] Univ Calif San Diego, CMM E, Ludwig Inst Canc Res, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, CMM E, Dept Cellular & Mol Med, La Jolla, CA 92093 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2008年 / 9卷 / 01期

关键词：

D O I：

10.1038/nrm2310

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Segregation of the replicated genome during cell division in eukaryotes requires the kinetochore to link centromeric DNA to spindle microtubules. The kinetochore is composed of a number of conserved protein complexes that direct its specification and assembly, bind to spindle microtubules and regulate chromosome segregation. Recent studies have identified more than 80 kinetochore components, and are revealing how these proteins are organized into the higher order kinetochore structure, as well as how they function to achieve proper chromosome segregation.

引用

页码：33 / 46

页数：14

共 167 条

[11] Centromere identity maintained by nucleosomes assembled with histone H3 containing the CENP-A targeting domain [J].

Black, Ben E. ;

Jansen, Lars E. T. ;

Maddox, Paul S. ;

Foltz, Daniel R. ;

Desai, Arshad B. ;

Shah, Jagesh V. ;

Cleveland, Don W. .

MOLECULAR CELL, 2007, 25 (02) :309-322

[12] Conserved organization of centromeric chromatin in flies and humans [J].

Blower, MD ;

Sullivan, BA ;

Karpen, GH .

DEVELOPMENTAL CELL, 2002, 2 (03) :319-330

[13] The role of Drosophila CID in kinetochore formation, cell-cycle progression and heterochromatin interactions [J].

Blower, MD ;

Karpen, GH .

NATURE CELL BIOLOGY, 2001, 3 (08) :730-739

[14] FINE STRUCTURE OF KINETOCHORE OF A MAMMALIAN CELL IN VITRO [J].

BRINKLEY, BR ;

STUBBLEFIELD, E .

CHROMOSOMA, 1966, 19 (01) :28-+

[15] Cell division -: A histone-H3-like protein in C-elegans [J].

Buchwitz, BJ ;

Ahmad, K ;

Moore, LL ;

Roth, MB ;

Henikoff, S .

NATURE, 1999, 401 (6753) :547-548

[16] Scm3 is essential to recruit the histone H3 variant Cse4 to centromeres and to maintain a functional kinetochore [J].

Camahort, Raymond ;

Li, Bing ;

Florens, Laurence ;

Swanson, Selene K. ;

Washburn, Michael P. ;

Gerton, Jennifer L. .

MOLECULAR CELL, 2007, 26 (06) :853-865

[17] The conserved KMN network constitutes the core microtubule-binding site of the kinetochore [J].

Cheeseman, Iain M. ;

Chappie, Joshua S. ;

Wilson-Kubalek, Elizabeth M. ;

Desai, Arshad .

CELL, 2006, 127 (05) :983-997

[18] The CENP-F-like proteins HCP-1 and HCP-2 target CLASP to kinetochores to mediate chromosome segregation [J].

Cheeseman, IM ;

MacLeod, I ;

Yates, JR ;

Oegema, K ;

Desai, A .

CURRENT BIOLOGY, 2005, 15 (08) :771-777

[19] A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension [J].

Cheeseman, IM ;

Niessen, S ;

Anderson, S ;

Hyndman, F ;

Yates, JR ;

Oegema, K ;

Desai, A .

GENES & DEVELOPMENT, 2004, 18 (18) :2255-2268

[20] Phospho-regulation of kinetochore-microtubule attachments by the aurora kinase Ipl1p [J].

Cheeseman, LM ;

Anderson, S ;

Jwa, M ;

Green, EM ;

Kang, JS ;

Yates, JR ;

Chan, CSM ;

Drubin, DG ;

Barnes, G .

CELL, 2002, 111 (02) :163-172

← 1 2 3 4 5 6 7 8 9 10 →