Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3

被引：660

作者：

Brand, MD ^{[1
]}

Esteves, TC ^{[1
]}

机构：

[1] MRC, Dunn Human Nutr Unit, Cambridge, England

来源：

CELL METABOLISM | 2005年 / 2卷 / 02期

关键词：

D O I：

10.1016/j.cmet.2005.06.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Evidence for the physiological functions of UCP2 and UCP3 is critically reviewed. They do not mediate adaptive thermogenesis, but they may be significantly thermogenic under specific pharmacological conditions. There is strong evidence that the mild regulated uncoupling they cause attenuates mitochondrial ROS production, protects against cellular damage, and diminishes insulin secretion. Evidence that they export fatty acids physiologically is weak. UCP2 and UCP3 are important potential targets for treatment of aging, degenerative diseases, diabetes, and perhaps obesity.

引用

收藏

页码：85 / 93

页数：9

相关论文

共 98 条

[61] A plant cold-induced uncoupling protein [J].

Laloi, M ;

Klein, M ;

Riesmeier, JW ;

MullerRober, B ;

Fleury, C ;

Bouillaud, F ;

Ricquier, D .

NATURE, 1997, 389 (6647) :135-136

[62] Superoxide production by NADH: ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane [J].

Lambert, AJ ;

Brand, MD .

BIOCHEMICAL JOURNAL, 2004, 382 :511-517

[63] Uncoupling protein 2: A possible link between fatty acid excess and impaired glucose-induced insulin secretion? [J].

Lameloise, N ;

Muzzin, P ;

Prentki, M ;

Assimacopoulos-Jeannet, F .

DIABETES, 2001, 50 (04) :803-809

[64] Uncoupling protein-2 participates in cellular defense against oxidative stress in clonal β-cells [J].

Li, LX ;

Skorpen, F ;

Egeberg, K ;

Jorgensen, IH ;

Grill, V .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 282 (01) :273-277

[65] Generating, partitioning, targeting and functioning of superoxide in mitochondria [J].

Liu, SS .

BIOSCIENCE REPORTS, 1997, 17 (03) :259-272

[66] Pharmacology: Uncoupling the agony from ecstasy - A mitochondrial protein may mediate a dangerous side-effect of some recreational drugs [J].

Mills, EM ;

Banks, ML ;

Sprague, JE ;

Finkel, T .

NATURE, 2003, 426 (6965) :403-404

[67] Inhibition of glucose-induced insulin secretion by 4-hydroxy-2-nonenal and other lipid peroxidation products [J].

Miwa, I ;

Ichimura, N ;

Sugiura, M ;

Hamada, Y ;

Taniguchi, S .

ENDOCRINOLOGY, 2000, 141 (08) :2767-2772

[68] Superoxide and hydrogen peroxide production by Drosophila mitochondria [J].

Miwa, S ;

St-Pierre, J ;

Partridge, L ;

Brand, MD .

FREE RADICAL BIOLOGY AND MEDICINE, 2003, 35 (08) :938-948

[69] Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation - Studies using a mitochondria-targeted spin trap derived from alpha-phenyl-N-tert-butylnitrone [J].

Murphy, MP ;

Echtay, KS ;

Blaikie, FH ;

Asin-Cayuela, J ;

Cocheme, HM ;

Green, K ;

Buckingham, JA ;

Taylor, ER ;

Hurrell, F ;

Hughes, G ;

Miwa, S ;

Cooper, CE ;

Svistunenko, DA ;

Smith, RAJ ;

Brand, MD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (49) :48534-48545

[70] The 'novel' 'ncoupling' proteins UCP2 and UCP3: what do they really do? Pros and cons for suggested functions [J].

Nedergaard, J ;

Cannon, B .

EXPERIMENTAL PHYSIOLOGY, 2003, 88 (01) :65-84

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