Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3

被引：660

作者：

Brand, MD ^{[1
]}

Esteves, TC ^{[1
]}

机构：

[1] MRC, Dunn Human Nutr Unit, Cambridge, England

来源：

CELL METABOLISM | 2005年 / 2卷 / 02期

关键词：

D O I：

10.1016/j.cmet.2005.06.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Evidence for the physiological functions of UCP2 and UCP3 is critically reviewed. They do not mediate adaptive thermogenesis, but they may be significantly thermogenic under specific pharmacological conditions. There is strong evidence that the mild regulated uncoupling they cause attenuates mitochondrial ROS production, protects against cellular damage, and diminishes insulin secretion. Evidence that they export fatty acids physiologically is weak. UCP2 and UCP3 are important potential targets for treatment of aging, degenerative diseases, diabetes, and perhaps obesity.

引用

收藏

页码：85 / 93

页数：9

相关论文

共 98 条

[91] Superoxide activates a GDP-sensitive proton conductance in skeletal muscle mitochondria from king penguin (Aptenodytes patagonicus) [J].

Talbot, DA ;

Hanuise, N ;

Rey, B ;

Rouanet, JL ;

Duchamp, C ;

Brand, MD .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 312 (04) :983-988

[92] Production of endogenous matrix superoxide from mitochondrial complex I leads to activation of uncoupling protein 3 [J].

Talbot, DA ;

Lambert, AJ ;

Brand, MD .

FEBS LETTERS, 2004, 556 (1-3) :111-115

[93] Cold-induced mitochondrial uncoupling and expression of chicken UCP and ANT mRNA in chicken skeletal muscle [J].

Toyomizu, M ;

Ueda, M ;

Sato, S ;

Seki, Y ;

Sato, K ;

Akiba, Y .

FEBS LETTERS, 2002, 529 (2-3) :313-318

[94] Cloning and functional characterization of an uncoupling protein homolog in hummingbirds [J].

Vianna, CR ;

Hagen, T ;

Zhang, CY ;

Bachman, E ;

Boss, O ;

Gereben, B ;

Moriscot, AS ;

Lowell, BB ;

Bicudo, JEPW ;

Bianco, AC .

PHYSIOLOGICAL GENOMICS, 2001, 5 (03) :137-145

[95] Energy metabolism in uncoupling protein 3 gene knockout mice [J].

Vidal-Puig, AJ ;

Grujic, D ;

Zhang, CY ;

Hagen, T ;

Boss, O ;

Ido, Y ;

Szczepanik, A ;

Wade, J ;

Mootha, V ;

Cortright, R ;

Muoio, DM ;

Lowell, BB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (21) :16258-16266

[96] UCP3: An uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue [J].

VidalPuig, A ;

Solanes, G ;

Grujic, D ;

Flier, JS ;

Lowell, BB .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 235 (01) :79-82

[97] Lithium-assisted self-assembly of aluminum carbide nanowires and nanoribbons [J].

Zhang, HF ;

Dohnalkova, AC ;

Wang, CM ;

Young, JS ;

Buck, EC ;

Wang, LS .

NANO LETTERS, 2002, 2 (02) :105-108

[98] Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation [J].

Zhou, YT ;

Shimabukuro, M ;

Koyama, K ;

Lee, Y ;

Wang, MY ;

Trieu, F ;

Newgard, CB ;

Unger, RH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (12) :6386-6390

← 1 2 3 4 5 6 7 8 9 10 →