Intracellular signaling from the endoplasmic reticulum to the nucleus

被引：199

作者：

Chapman, R ^{[1
]}

Sidrauski, C

Walter, P

机构：

[1] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA

来源：

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 1998年 / 14卷

关键词：

mRNA splicing; tRNA ligase; transmembrane kinase; transcriptional regulation; translation regulation;

D O I：

10.1146/annurev.cellbio.14.1.459

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cells respond to an accumulation of unfolded proteins in the endoplasmic reticulum (ER) by increasing transcription of genes encoding ER resident proteins. The information is transmitted from the ER lumen to the nucleus by an intracellular signaling pathway called the unfolded protein response (UPR). Recent work has shown that this signaling pathway utilizes several novel mechanisms, including translational attenuation and a regulated mRNA splicing step. In this review we aim to integrate these recent advances with current knowledge about maintenance of ER composition and abundance.

引用

页码：459 / 485

页数：27

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