QUALITY-CONTROL IN THE SECRETORY PATHWAY

被引：551

作者：

HAMMOND, C

HELENIUS, A

机构：

[1] Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06511

来源：

CURRENT OPINION IN CELL BIOLOGY | 1995年 / 7卷 / 04期

关键词：

D O I：

10.1016/0955-0674(95)80009-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Whereas newly synthesized proteins that have aquired a properly folded and assembled structure are transported from the endoplasmic reticulum to their final destinations, incompletely folded and assembled proteins are, as a rule, retained and eventually degraded. The molecular mechanisms of this unique molecular sorting phenomenon, called 'quality control', have been illuminated by recent studies.

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页码：523 / 529

页数：7

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