The cortical topography of human swallowing musculature in health and disease

被引:360
作者
Hamdy, S
Aziz, Q
Rothwell, JC
Singh, KD
Barlow, J
Hughes, DG
Tallis, RC
Thompson, DG
机构
[1] UNIV MANCHESTER, HOPE HOSP, DEPT GASTROENTEROL, MANCHESTER M6 8HD, LANCS, ENGLAND
[2] UNIV MANCHESTER, HOPE HOSP, DEPT NEURORADIOL, MANCHESTER M6 8HD, LANCS, ENGLAND
[3] UNIV MANCHESTER, HOPE HOSP, DEPT GERIATR MED, MANCHESTER M6 8HD, LANCS, ENGLAND
[4] INST NEUROL, MRC, HUMAN MOVEMENT & BALANCE UNIT, LONDON WC1N 3BG, ENGLAND
[5] ASTON UNIV, DEPT VIS SCI, BIRMINGHAM B4 7ET, W MIDLANDS, ENGLAND
关键词
D O I
10.1038/nm1196-1217
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Because no detailed information exists regarding the topographic representation of swallowing musculature on the human cerebral cortex in health or disease, we used transcranial magnetic stimulation to study the cortical topography of human oral, pharyngeal and esophageal musculature in 20 healthy individuals and the topography of pharyngeal musculature in two stroke patients, one with and one without dysphagia. Our results demonstrate that swallowing musculature is discretely and somatotopically represented on the motor and premotor cortex of both hemispheres but displays interhemispheric asymmetry, independent of handedness. Following stroke, dysphagia appeared to be associated with smaller pharyngeal representation on the intact hemisphere, which increases in size with recovery of swallowing.
引用
收藏
页码:1217 / 1224
页数:8
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