Genome-Wide Analysis of Blood Pressure Variability and Ischemic Stroke

被引：23

作者：

Yadav, Sunaina ^{[1
]}

Cotlarciuc, Ioana ^{[1
]}

Munroe, Patricia B. ^{[24
]}

Khan, Muhammad S. ^{[1
]}

Nalls, Michael A. ^{[12
]}

Bevan, Steve ^{[9
]}

Cheng, Yu-Ching ^{[11
,27
]}

Chen, Wei-Min ^{[15
,16
]}

Malik, Rainer ^{[7
,8
]}

McCarthy, Nina S. ^{[21
,22
]}

Holliday, Elizabeth G. ^{[3
,6
]}

Speed, Douglas ^{[19
]}

Hasan, Nazeeha ^{[1
]}

Pucek, Mateusz ^{[1
]}

Rinne, Paul E. ^{[1
]}

Sever, Peter ^{[1
,2
]}

Stanton, Alice ^{[22
]}

Shields, Denis C. ^{[23
]}

Maguire, Jane M. ^{[4
,6
,25
]}

McEvoy, Mark ^{[3
,6
]}

Scott, Rodney J. ^{[5
,6
,26
]}

Ferrucci, Luigi ^{[28
]}

Macleod, Mary J. ^{[20
]}

Attia, John ^{[3
,6
]}

Markus, Hugh S. ^{[9
]}

Sale, Michele M. ^{[14
,15
]}

Worrall, Bradford B. ^{[13
]}

Mitchell, Braxton D. ^{[27
]}

Dichgans, Martin ^{[7
,8
]}

Sudlow, Cathy ^{[17
]}

Meschia, James F. ^{[10
]}

Rothwell, Peter M. ^{[18
]}

Caulfield, Mark ^{[24
]}

Sharma, Pankaj

机构：

[1] Imperial Coll London, Imperial Coll Cerebrovascular Res Unit, London, England

[2] Imperial Coll Cerebrovasc Res Unit, London, England

[3] Univ Newcastle, Ctr Clin Epidemiol & Biostat, Sch Med & Publ Hlth, Newcastle, NSW 2300, Australia

[4] Univ Newcastle, Sch Nursing & Midwifery, Newcastle, NSW 2300, Australia

[5] Univ Newcastle, Sch Biomed Sci & Pharm, Newcastle, NSW 2300, Australia

[6] Hunter Med Res Inst, Newcastle, NSW, Australia

[7] Univ Munich, Inst Stroke & Dementia Res ISD, Med Ctr, Klinikum Univ Munchen, Munich, Germany

[8] Munich Cluster Syst Neurol SyNergy, Munich, Germany

[9] St Georges Univ London, Stroke & Dementia Res Ctr, London, England

[10] Mayo Clin, Dept Neurol, Jacksonville, FL 32224 USA

[11] Baltimore Vet Affairs Med Ctr, Baltimore, MD USA

[12] US Natl Inst Hlth, Natl Inst Aging, Neurogenet Lab, Bethesda, MD USA

[13] Univ Virginia, Dept Neurol & Publ Hlth Sci, Charlottesville, VA USA

[14] Univ Virginia, Div Cardiovasc Med, Dept Internal Med, Charlottesville, VA USA

[15] Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA

[16] Univ Virginia, Dept Publ Hlth Sci, Charlottesville, VA USA

[17] Univ Edinburgh, Inst Genet & Mol Med, Div Clin Neurosci, Edinburgh, Midlothian, Scotland

[18] John Radcliffe Hosp, Dept Clin Neurol, Oxford OX3 9DU, England

[19] UCL, UCL Genet Inst, London, England

[20] Univ Aberdeen, Div Appl Med, Aberdeen, Scotland

[21] Univ Western Australia, Ctr Genet Origins Hlth & Dis, Crawley, WA, Australia

[22] Royal Coll Surgeons Ireland, Dublin 2, Ireland

[23] Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Dublin 4, Ireland

[24] Barts & London Med Sch, William Harvey Res Inst, Ctr Clin Pharmacol, London, England

[25] Gosford Hosp, Dept Neurosci, Gosford, NSW, Australia

[26] Hunter Area Pathol Serv, Div Genet, Newcastle, NSW, Australia

[27] Univ Maryland, Dept Med, Baltimore, MD 21201 USA

[28] NIH, Natl Inst Aging, Clin Res Branch, Longitudinal Studies Sect, Baltimore, MD USA

来源：

STROKE | 2013年 / 44卷 / 10期

基金：

英国惠康基金; 新加坡国家研究基金会; 美国国家卫生研究院; 英国医学研究理事会;

关键词：

blood pressure variability; genes; GWAS; polymorphism; stroke; POPULATION-STRUCTURE; COMMON VARIANTS; BIO-REPOSITORY; RISK-FACTORS; ASSOCIATION; METAANALYSIS; PREVENTION; INFARCTION; RATIONALE; EFFICIENT;

D O I：

10.1161/STROKEAHA.113.002186

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose Visit-to-visit variability in blood pressure (vBP) is associated with ischemic stroke. We sought to determine whether such variability has genetic causes and whether genetic variants associated with BP variability are also associated with ischemic stroke. Methods A Genome Wide Association Study (GWAS) for loci influencing BP variability was undertaken in 3802 individuals from the Anglo-Scandinavian Cardiac Outcome Trial (ASCOT) study, in which long-term visit-to-visit and within-visit BP measures were available. Because BP variability is strongly associated with ischemic stroke, we genotyped the sentinel single nucleotide polymorphism in an independent ischemic stroke population comprising 8624 cases and 12 722 controls and in 3900 additional (Scandinavian) participants from the ASCOT study to replicate our findings. Results The ASCOT discovery GWAS identified a cluster of 17 correlated single nucleotide polymorphisms within the NLGN1 gene (3q26.31) associated with BP variability. The strongest association was with rs976683 (P=1.4x10(-8)). Conditional analysis of rs976683 provided no evidence of additional independent associations at the locus. Analysis of rs976683 in patients with ischemic stroke found no association for overall stroke (odds ratio, 1.02; 95% CI, 0.97-1.07; P=0.52) or its subtypes: cardioembolic (odds ratio, 1.07; 95% CI, 0.97-1.16; P=0.17), large vessel disease (odds ratio, 0.98; 95% CI, 0.89-1.07; P=0.60), and small vessel disease (odds ratio, 1.07; 95% CI, 0.97-1.17; P=0.19). No evidence for association was found between rs976683 and BP variability in the additional (Scandinavian) ASCOT participants (P=0.18). Conclusions We identified a cluster of single nucleotide polymorphisms at the NLGN1 locus showing significant association with BP variability. Follow-up analyses did not support an association with risk of ischemic stroke and its subtypes.

引用

页码：2703 / 2709

页数：7

共 41 条

[11] Autism genome-wide copy number variation reveals ubiquitin and neuronal genes [J].

Glessner, Joseph T. ;

Wang, Kai ;

Cai, Guiqing ;

Korvatska, Olena ;

Kim, Cecilia E. ;

Wood, Shawn ;

Zhang, Haitao ;

Estes, Annette ;

Brune, Camille W. ;

Bradfield, Jonathan P. ;

Imielinski, Marcin ;

Frackelton, Edward C. ;

Reichert, Jennifer ;

Crawford, Emily L. ;

Munson, Jeffrey ;

Sleiman, Patrick M. A. ;

Chiavacci, Rosetta ;

Annaiah, Kiran ;

Thomas, Kelly ;

Hou, Cuiping ;

Glaberson, Wendy ;

Flory, James ;

Otieno, Frederick ;

Garris, Maria ;

Soorya, Latha ;

Klei, Lambertus ;

Piven, Joseph ;

Meyer, Kacie J. ;

Anagnostou, Evdokia ;

Sakurai, Takeshi ;

Game, Rachel M. ;

Rudd, Danielle S. ;

Zurawiecki, Danielle ;

McDougle, Christopher J. ;

Davis, Lea K. ;

Miller, Judith ;

Posey, David J. ;

Michaels, Shana ;

Kolevzon, Alexander ;

Silverman, Jeremy M. ;

Bernier, Raphael ;

Levy, Susan E. ;

Schultz, Robert T. ;

Dawson, Geraldine ;

Owley, Thomas ;

McMahon, William M. ;

Wassink, Thomas H. ;

Sweeney, John A. ;

Nurnberger, John I., Jr. ;

Coon, Hilary .

NATURE, 2009, 459 (7246) :569-573

[12] Common variants at 6p21.1 are associated with large artery atherosclerotic stroke [J].

Holliday, Elizabeth G. ;

Maguire, Jane M. ;

Evans, Tiffany-Jane ;

Koblar, Simon A. ;

Jannes, Jim ;

Sturm, Jonathan W. ;

Hankey, Graeme J. ;

Baker, Ross ;

Golledge, Jonathan ;

Parsons, Mark W. ;

Malik, Rainer ;

McEvoy, Mark ;

Biros, Erik ;

Lewis, Martin D. ;

Lincz, Lisa F. ;

Peel, Roseanne ;

Oldmeadow, Christopher ;

Smith, Wayne ;

Moscato, Pablo ;

Barlera, Simona ;

Bevan, Steve ;

Bis, Joshua C. ;

Boerwinkle, Eric ;

Boncoraglio, Giorgio B. ;

Brott, Thomas G. ;

Brown, Robert D., Jr. ;

Cheng, Yu-Ching ;

Cole, John W. ;

Cotlarciuc, Ioana ;

Devan, William J. ;

Fornage, Myriam ;

Furie, Karen L. ;

Gretarsdottir, Solveig ;

Gschwendtner, Andreas ;

Ikram, M. Arfan ;

Longstreth, W. T., Jr. ;

Meschia, James F. ;

Mitchell, Braxton D. ;

Mosley, Thomas H. ;

Nalls, Michael A. ;

Parati, Eugenio A. ;

Psaty, Bruce M. ;

Sharma, Pankaj ;

Stefansson, Kari ;

Thorleifsson, Gudmar ;

Thorsteinsdottir, Unnur ;

Traylor, Matthew ;

Verhaaren, Benjamin F. J. ;

Wiggins, Kerri L. ;

Worrall, Bradford B. .

NATURE GENETICS, 2012, 44 (10) :1147-+

[13] The Genetic Structure of the Swedish Population [J].

Humphreys, Keith ;

Grankvist, Alexander ;

Leu, Monica ;

Hall, Per ;

Liu, Jianjun ;

Ripatti, Samuli ;

Rehnstroem, Karola ;

Groop, Leif ;

Klareskog, Lars ;

Ding, Bo ;

Gronberg, Henrik ;

Xu, Jianfeng ;

Pedersen, Nancy L. ;

Lichtenstein, Paul ;

Mattingsdal, Morten ;

Andreassen, Ole A. ;

O'Dushlaine, Colm ;

Purcell, Shaun M. ;

Sklar, Pamela ;

Sullivan, Patrick F. ;

Hultman, Christina M. ;

Palmgren, Juni ;

Magnusson, Patrik K. E. .

PLOS ONE, 2011, 6 (08)

[14] Blood Pressure Loci Identified with a Gene-Centric Array [J].

Johnson, Toby ;

Gaunt, Tom R. ;

Newhouse, Stephen J. ;

Padmanabhan, Sandosh ;

Tomaszewski, Maciej ;

Kumari, Meena ;

Morris, Richard W. ;

Tzoulaki, Ioanna ;

O'Brien, Eoin T. ;

Poulter, Neil R. ;

Sever, Peter ;

Shields, Denis C. ;

Thom, Simon ;

Wannamethee, Sasiwarang G. ;

Whincup, Peter H. ;

Brown, Morris J. ;

Connell, John M. ;

Dobson, Richard J. ;

Howard, Philip J. ;

Mein, Charles A. ;

Onipinla, Abiodun ;

Shaw-Hawkins, Sue ;

Zhang, Yun ;

Smith, George Davey ;

Day, Ian N. M. ;

Lawlor, Debbie A. ;

Goodall, Alison H. ;

Fowkes, F. Gerald ;

Abecasis, Goncalo R. ;

Elliott, Paul ;

Gateva, Vesela ;

Braund, Peter S. ;

Burton, Paul R. ;

Nelson, Christopher P. ;

Tobin, Martin D. ;

van der Harst, Pim ;

Glorioso, Nicola ;

Neuvrith, Hani ;

Salvi, Erika ;

Staessen, Jan A. ;

Stucchi, Andrea ;

Devos, Nabila ;

Jeunemaitre, Xavier ;

Plouin, Pierre-Francois ;

Tichet, Jean ;

Juhanson, Peeter ;

Org, Elin ;

Putku, Margus ;

Sober, Siim ;

Veldre, Gudrun .

AMERICAN JOURNAL OF HUMAN GENETICS, 2011, 89 (06) :688-700

[15] Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians [J].

Kato, Norihiro ;

Takeuchi, Fumihiko ;

Tabara, Yasuharu ;

Kelly, Tanika N. ;

Go, Min Jin ;

Sim, Xueling ;

Tay, Wan Ting ;

Chen, Chien-Hsiun ;

Zhang, Yi ;

Yamamoto, Ken ;

Katsuya, Tomohiro ;

Yokota, Mitsuhiro ;

Kim, Young Jin ;

Ong, Rick Twee Hee ;

Nabika, Toru ;

Gu, Dongfeng ;

Chang, Li-Ching ;

Kokubo, Yoshihiro ;

Huang, Wei ;

Ohnaka, Keizo ;

Yamori, Yukio ;

Nakashima, Eitaro ;

Jaquish, Cashell E. ;

Lee, Jong-Young ;

Seielstad, Mark ;

Isono, Masato ;

Hixson, James E. ;

Chen, Yuan-Tsong ;

Miki, Tetsuro ;

Zhou, Xueya ;

Sugiyama, Takao ;

Jeon, Jae-Pil ;

Liu, Jian Jun ;

Takayanagi, Ryoichi ;

Kim, Sung Soo ;

Aung, Tin ;

Sung, Yun Ju ;

Zhang, Xuegong ;

Wong, Tien Yin ;

Han, Bok-Ghee ;

Kobayashi, Shotai ;

Ogihara, Toshio ;

Zhu, Dingliang ;

Iwai, Naoharu ;

Wu, Jer-Yuarn ;

Teo, Yik Ying ;

Tai, E. Shyong ;

Cho, Yoon Shin ;

He, Jiang .

NATURE GENETICS, 2011, 43 (06) :530-U57

[16] Cerebral infarction in young adults - The Baltimore-Washington cooperative young stroke study [J].

Kittner, SJ ;

Stern, BJ ;

Wozniak, M ;

Buchholz, DW ;

Earley, CJ ;

Feeser, BR ;

Johnson, CJ ;

Macko, RF ;

McCarter, RJ ;

Price, TR ;

Sherwin, R ;

Sloan, MA ;

Wityk, RJ .

NEUROLOGY, 1998, 50 (04) :890-894

[17] Correlation between genetic and geographic structure in Europe [J].

Lao, Oscar ;

Lu, Timothy T. ;

Nothnagel, Michael ;

Junge, Olaf ;

Freitag-Wolf, Sandra ;

Caliebe, Amke ;

Balascakova, Miroslava ;

Bertranpetit, Jaume ;

Bindoff, Laurence A. ;

Comas, David ;

Hoimlund, Gunilla ;

Kouvatsi, Anastasia ;

Macek, Milan ;

Mollet, Isabelle ;

Parson, Walther ;

Palo, Jukka ;

Ploski, Rafal ;

Sajantila, Antti ;

Tagliabracci, Adriano ;

Gether, Ulrik ;

Werge, Thomas ;

Rivadeneira, Fernando ;

Hofman, Albert ;

Uitterlinden, Andre G. ;

Gieger, Christian ;

Wichmann, Heinz-Erich ;

Ruether, Andreas ;

Schreiber, Stefan ;

Becker, Christian ;

Nuernberg, Peter ;

Nelson, Matthew R. ;

Krawczak, Michael ;

Kayser, Manfred .

CURRENT BIOLOGY, 2008, 18 (16) :1241-1248

[18] Genome-wide scan of granular corneal dystrophy, type II: confirmation of chromosome 5q31 and identification of new co-segregated loci on chromosome 3q26.3 [J].

Lee, Eun-Ju ;

Kim, Kwang Joong ;

Kim, Han-Na ;

Bok, Jeong ;

Jung, Sung-Chul ;

Kim, Eung Kweon ;

Lee, Jong-Young ;

Kim, Hyung-Lae .

EXPERIMENTAL AND MOLECULAR MEDICINE, 2011, 43 (07) :393-400

[19] UK stroke incidence, mortality and cardiovascular risk management 1999-2008: time-trend analysis from the General Practice Research Database [J].

Lee, Sally ;

Shafe, Anna C. E. ;

Cowie, Martin R. .

BMJ OPEN, 2011, 1 (02)

[20] Genome-wide association study of blood pressure and hypertension [J].

Levy, Daniel ;

Ehret, Georg B. ;

Rice, Kenneth ;

Verwoert, Germaine C. ;

Launer, Lenore J. ;

Dehghan, Abbas ;

Glazer, Nicole L. ;

Morrison, Alanna C. ;

Johnson, Andrew D. ;

Aspelund, Thor ;

Aulchenko, Yurii ;

Lumley, Thomas ;

Koettgen, Anna ;

Vasan, Ramachandran S. ;

Rivadeneira, Fernando ;

Eiriksdottir, Gudny ;

Guo, Xiuqing ;

Arking, Dan E. ;

Mitchell, Gary F. ;

Mattace-Raso, Francesco U. S. ;

Smith, Albert V. ;

Taylor, Kent ;

Scharpf, Robert B. ;

Hwang, Shih-Jen ;

Sijbrands, Eric J. G. ;

Bis, Joshua ;

Harris, Tamara B. ;

Ganesh, Santhi K. ;

O'Donnell, Christopher J. ;

Hofman, Albert ;

Rotter, Jerome I. ;

Coresh, Josef ;

Benjamin, Emelia J. ;

Uitterlinden, Andre G. ;

Heiss, Gerardo ;

Fox, Caroline S. ;

Witteman, Jacqueline C. M. ;

Boerwinkle, Eric ;

Wang, Thomas J. ;

Gudnason, Vilmundur ;

Larson, Martin G. ;

Chakravarti, Aravinda ;

Psaty, Bruce M. ;

van Duijn, Cornelia M. .

NATURE GENETICS, 2009, 41 (06) :677-687

← 1 2 3 4 5 →

共 41 条

[11] Autism genome-wide copy number variation reveals ubiquitin and neuronal genes [J].

Glessner, Joseph T. ;

Wang, Kai ;

Cai, Guiqing ;

Korvatska, Olena ;

Kim, Cecilia E. ;

Wood, Shawn ;

Zhang, Haitao ;

Estes, Annette ;

Brune, Camille W. ;

Bradfield, Jonathan P. ;

Imielinski, Marcin ;

Frackelton, Edward C. ;

Reichert, Jennifer ;

Crawford, Emily L. ;

Munson, Jeffrey ;

Sleiman, Patrick M. A. ;

Chiavacci, Rosetta ;

Annaiah, Kiran ;

Thomas, Kelly ;

Hou, Cuiping ;

Glaberson, Wendy ;

Flory, James ;

Otieno, Frederick ;

Garris, Maria ;

Soorya, Latha ;

Klei, Lambertus ;

Piven, Joseph ;

Meyer, Kacie J. ;

Anagnostou, Evdokia ;

Sakurai, Takeshi ;

Game, Rachel M. ;

Rudd, Danielle S. ;

Zurawiecki, Danielle ;

McDougle, Christopher J. ;

Davis, Lea K. ;

Miller, Judith ;

Posey, David J. ;

Michaels, Shana ;

Kolevzon, Alexander ;

Silverman, Jeremy M. ;

Bernier, Raphael ;

Levy, Susan E. ;

Schultz, Robert T. ;

Dawson, Geraldine ;

Owley, Thomas ;

McMahon, William M. ;

Wassink, Thomas H. ;

Sweeney, John A. ;

Nurnberger, John I., Jr. ;

Coon, Hilary .

NATURE, 2009, 459 (7246) :569-573

[12] Common variants at 6p21.1 are associated with large artery atherosclerotic stroke [J].

Holliday, Elizabeth G. ;

Maguire, Jane M. ;

Evans, Tiffany-Jane ;

Koblar, Simon A. ;

Jannes, Jim ;

Sturm, Jonathan W. ;

Hankey, Graeme J. ;

Baker, Ross ;

Golledge, Jonathan ;

Parsons, Mark W. ;

Malik, Rainer ;

McEvoy, Mark ;

Biros, Erik ;

Lewis, Martin D. ;

Lincz, Lisa F. ;

Peel, Roseanne ;

Oldmeadow, Christopher ;

Smith, Wayne ;

Moscato, Pablo ;

Barlera, Simona ;

Bevan, Steve ;

Bis, Joshua C. ;

Boerwinkle, Eric ;

Boncoraglio, Giorgio B. ;

Brott, Thomas G. ;

Brown, Robert D., Jr. ;

Cheng, Yu-Ching ;

Cole, John W. ;

Cotlarciuc, Ioana ;

Devan, William J. ;

Fornage, Myriam ;

Furie, Karen L. ;

Gretarsdottir, Solveig ;

Gschwendtner, Andreas ;

Ikram, M. Arfan ;

Longstreth, W. T., Jr. ;

Meschia, James F. ;

Mitchell, Braxton D. ;

Mosley, Thomas H. ;

Nalls, Michael A. ;

Parati, Eugenio A. ;

Psaty, Bruce M. ;

Sharma, Pankaj ;

Stefansson, Kari ;

Thorleifsson, Gudmar ;

Thorsteinsdottir, Unnur ;

Traylor, Matthew ;

Verhaaren, Benjamin F. J. ;

Wiggins, Kerri L. ;

Worrall, Bradford B. .

NATURE GENETICS, 2012, 44 (10) :1147-+

[13] The Genetic Structure of the Swedish Population [J].

Humphreys, Keith ;

Grankvist, Alexander ;

Leu, Monica ;

Hall, Per ;

Liu, Jianjun ;

Ripatti, Samuli ;

Rehnstroem, Karola ;

Groop, Leif ;

Klareskog, Lars ;

Ding, Bo ;

Gronberg, Henrik ;

Xu, Jianfeng ;

Pedersen, Nancy L. ;

Lichtenstein, Paul ;

Mattingsdal, Morten ;

Andreassen, Ole A. ;

O'Dushlaine, Colm ;

Purcell, Shaun M. ;

Sklar, Pamela ;

Sullivan, Patrick F. ;

Hultman, Christina M. ;

Palmgren, Juni ;

Magnusson, Patrik K. E. .

PLOS ONE, 2011, 6 (08)

[14] Blood Pressure Loci Identified with a Gene-Centric Array [J].

Johnson, Toby ;

Gaunt, Tom R. ;

Newhouse, Stephen J. ;

Padmanabhan, Sandosh ;

Tomaszewski, Maciej ;

Kumari, Meena ;

Morris, Richard W. ;

Tzoulaki, Ioanna ;

O'Brien, Eoin T. ;

Poulter, Neil R. ;

Sever, Peter ;

Shields, Denis C. ;

Thom, Simon ;

Wannamethee, Sasiwarang G. ;

Whincup, Peter H. ;

Brown, Morris J. ;

Connell, John M. ;

Dobson, Richard J. ;

Howard, Philip J. ;

Mein, Charles A. ;

Onipinla, Abiodun ;

Shaw-Hawkins, Sue ;

Zhang, Yun ;

Smith, George Davey ;

Day, Ian N. M. ;

Lawlor, Debbie A. ;

Goodall, Alison H. ;

Fowkes, F. Gerald ;

Abecasis, Goncalo R. ;

Elliott, Paul ;

Gateva, Vesela ;

Braund, Peter S. ;

Burton, Paul R. ;

Nelson, Christopher P. ;

Tobin, Martin D. ;

van der Harst, Pim ;

Glorioso, Nicola ;

Neuvrith, Hani ;

Salvi, Erika ;

Staessen, Jan A. ;

Stucchi, Andrea ;

Devos, Nabila ;

Jeunemaitre, Xavier ;

Plouin, Pierre-Francois ;

Tichet, Jean ;

Juhanson, Peeter ;

Org, Elin ;

Putku, Margus ;

Sober, Siim ;

Veldre, Gudrun .

AMERICAN JOURNAL OF HUMAN GENETICS, 2011, 89 (06) :688-700

[15] Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians [J].

Kato, Norihiro ;

Takeuchi, Fumihiko ;

Tabara, Yasuharu ;

Kelly, Tanika N. ;

Go, Min Jin ;

Sim, Xueling ;

Tay, Wan Ting ;

Chen, Chien-Hsiun ;

Zhang, Yi ;

Yamamoto, Ken ;

Katsuya, Tomohiro ;

Yokota, Mitsuhiro ;

Kim, Young Jin ;

Ong, Rick Twee Hee ;

Nabika, Toru ;

Gu, Dongfeng ;

Chang, Li-Ching ;

Kokubo, Yoshihiro ;

Huang, Wei ;

Ohnaka, Keizo ;

Yamori, Yukio ;

Nakashima, Eitaro ;

Jaquish, Cashell E. ;

Lee, Jong-Young ;

Seielstad, Mark ;

Isono, Masato ;

Hixson, James E. ;

Chen, Yuan-Tsong ;

Miki, Tetsuro ;

Zhou, Xueya ;

Sugiyama, Takao ;

Jeon, Jae-Pil ;

Liu, Jian Jun ;

Takayanagi, Ryoichi ;

Kim, Sung Soo ;

Aung, Tin ;

Sung, Yun Ju ;

Zhang, Xuegong ;

Wong, Tien Yin ;

Han, Bok-Ghee ;

Kobayashi, Shotai ;

Ogihara, Toshio ;

Zhu, Dingliang ;

Iwai, Naoharu ;

Wu, Jer-Yuarn ;

Teo, Yik Ying ;

Tai, E. Shyong ;

Cho, Yoon Shin ;

He, Jiang .

NATURE GENETICS, 2011, 43 (06) :530-U57

[16] Cerebral infarction in young adults - The Baltimore-Washington cooperative young stroke study [J].

Kittner, SJ ;

Stern, BJ ;

Wozniak, M ;

Buchholz, DW ;

Earley, CJ ;

Feeser, BR ;

Johnson, CJ ;

Macko, RF ;

McCarter, RJ ;

Price, TR ;

Sherwin, R ;

Sloan, MA ;

Wityk, RJ .

NEUROLOGY, 1998, 50 (04) :890-894

[17] Correlation between genetic and geographic structure in Europe [J].

Lao, Oscar ;

Lu, Timothy T. ;

Nothnagel, Michael ;

Junge, Olaf ;

Freitag-Wolf, Sandra ;

Caliebe, Amke ;

Balascakova, Miroslava ;

Bertranpetit, Jaume ;

Bindoff, Laurence A. ;

Comas, David ;

Hoimlund, Gunilla ;

Kouvatsi, Anastasia ;

Macek, Milan ;

Mollet, Isabelle ;

Parson, Walther ;

Palo, Jukka ;

Ploski, Rafal ;

Sajantila, Antti ;

Tagliabracci, Adriano ;

Gether, Ulrik ;

Werge, Thomas ;

Rivadeneira, Fernando ;

Hofman, Albert ;

Uitterlinden, Andre G. ;

Gieger, Christian ;

Wichmann, Heinz-Erich ;

Ruether, Andreas ;

Schreiber, Stefan ;

Becker, Christian ;

Nuernberg, Peter ;

Nelson, Matthew R. ;

Krawczak, Michael ;

Kayser, Manfred .

CURRENT BIOLOGY, 2008, 18 (16) :1241-1248

[18] Genome-wide scan of granular corneal dystrophy, type II: confirmation of chromosome 5q31 and identification of new co-segregated loci on chromosome 3q26.3 [J].

Lee, Eun-Ju ;

Kim, Kwang Joong ;

Kim, Han-Na ;

Bok, Jeong ;

Jung, Sung-Chul ;

Kim, Eung Kweon ;

Lee, Jong-Young ;

Kim, Hyung-Lae .

EXPERIMENTAL AND MOLECULAR MEDICINE, 2011, 43 (07) :393-400

[19] UK stroke incidence, mortality and cardiovascular risk management 1999-2008: time-trend analysis from the General Practice Research Database [J].

Lee, Sally ;

Shafe, Anna C. E. ;

Cowie, Martin R. .

BMJ OPEN, 2011, 1 (02)

[20] Genome-wide association study of blood pressure and hypertension [J].

Levy, Daniel ;

Ehret, Georg B. ;

Rice, Kenneth ;

Verwoert, Germaine C. ;

Launer, Lenore J. ;

Dehghan, Abbas ;

Glazer, Nicole L. ;

Morrison, Alanna C. ;

Johnson, Andrew D. ;

Aspelund, Thor ;

Aulchenko, Yurii ;

Lumley, Thomas ;

Koettgen, Anna ;

Vasan, Ramachandran S. ;

Rivadeneira, Fernando ;

Eiriksdottir, Gudny ;

Guo, Xiuqing ;

Arking, Dan E. ;

Mitchell, Gary F. ;

Mattace-Raso, Francesco U. S. ;

Smith, Albert V. ;

Taylor, Kent ;

Scharpf, Robert B. ;

Hwang, Shih-Jen ;

Sijbrands, Eric J. G. ;

Bis, Joshua ;

Harris, Tamara B. ;

Ganesh, Santhi K. ;

O'Donnell, Christopher J. ;

Hofman, Albert ;

Rotter, Jerome I. ;

Coresh, Josef ;

Benjamin, Emelia J. ;

Uitterlinden, Andre G. ;

Heiss, Gerardo ;

Fox, Caroline S. ;

Witteman, Jacqueline C. M. ;

Boerwinkle, Eric ;

Wang, Thomas J. ;

Gudnason, Vilmundur ;

Larson, Martin G. ;

Chakravarti, Aravinda ;

Psaty, Bruce M. ;

van Duijn, Cornelia M. .

NATURE GENETICS, 2009, 41 (06) :677-687

← 1 2 3 4 5 →