Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians

被引：461

作者：

Kato, Norihiro ^{[43
]}

Takeuchi, Fumihiko ^{[43
]}

Tabara, Yasuharu ^{[1
]}

Kelly, Tanika N. ^{[2
]}

Go, Min Jin ^{[3
]}

Sim, Xueling ^{[4
]}

Tay, Wan Ting ^{[5
]}

Chen, Chien-Hsiun ^{[6
,7
]}

Zhang, Yi ^{[8
,9
]}

Yamamoto, Ken ^{[10
]}

Katsuya, Tomohiro ^{[11
]}

Yokota, Mitsuhiro ^{[12
]}

Kim, Young Jin ^{[3
]}

Ong, Rick Twee Hee ^{[13
]}

Nabika, Toru ^{[14
]}

Gu, Dongfeng ^{[15
,16
,17
,18
]}

Chang, Li-Ching ^{[6
]}

Kokubo, Yoshihiro ^{[19
]}

Huang, Wei ^{[20
]}

Ohnaka, Keizo ^{[21
]}

Yamori, Yukio ^{[22
]}

Nakashima, Eitaro ^{[23
,24
]}

Jaquish, Cashell E. ^{[25
]}

Lee, Jong-Young ^{[3
]}

Seielstad, Mark ^{[26
]}

Isono, Masato ^{[43
]}

Hixson, James E. ^{[27
]}

Chen, Yuan-Tsong ^{[6
]}

Miki, Tetsuro ^{[28
]}

Zhou, Xueya ^{[29
]}

Sugiyama, Takao ^{[30
]}

Jeon, Jae-Pil ^{[3
]}

Liu, Jian Jun ^{[31
]}

Takayanagi, Ryoichi ^{[32
]}

Kim, Sung Soo ^{[3
]}

Aung, Tin ^{[5
,33
]}

Sung, Yun Ju ^{[34
]}

Zhang, Xuegong ^{[29
]}

Wong, Tien Yin ^{[5
,33
,35
]}

Han, Bok-Ghee ^{[3
]}

Kobayashi, Shotai ^{[36
]}

Ogihara, Toshio ^{[37
]}

Zhu, Dingliang ^{[8
,9
]}

Iwai, Naoharu ^{[38
]}

Wu, Jer-Yuarn ^{[6
,7
]}

Teo, Yik Ying ^{[4
,13
,30
,39
,40
]}

Tai, E. Shyong ^{[40
,41
]}

Cho, Yoon Shin ^{[3
]}

He, Jiang ^{[2
,42
]}

机构：

[1] Ehime Univ, Grad Sch Med, Dept Basic Med Res & Educ, Toon, Japan

[2] Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA

[3] Natl Inst Hlth, Ctr Genome Sci, Chungcheongbuk Do, South Korea

[4] Natl Univ Singapore, Ctr Mol Epidemiol, Singapore 117548, Singapore

[5] Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore

[6] Acad Sinica, Inst Biomed Sci, Taipei, Taiwan

[7] China Med Univ, Sch Chinese Med, Taichung, Taiwan

[8] Shanghai Jiao Tong Univ, Sch Med, Shanghai Rui Jin Hosp, State Key Lab Med Genet, Shanghai 200030, Peoples R China

[9] Shanghai Res Inst Hypertens, Shanghai, Peoples R China

[10] Kyushu Univ, Med Inst Bioregulat, Div Genome Anal, Fukuoka 812, Japan

[11] Osaka Univ, Grad Sch Med, Dept Clin Gene Therapy, Suita, Osaka, Japan

[12] Aichi Gakuin Univ, Sch Dent, Dept Genome Sci, Nagoya, Aichi 464, Japan

[13] Natl Univ Singapore, Grad Sch Integrat Sci & Engn, Singapore 117548, Singapore

[14] Shimane Univ, Sch Med, Dept Funct Pathol, Izumo, Shimane, Japan

[15] Chinese Acad Med Sci, Cardiovasc Inst, Beijing 100037, Peoples R China

[16] Chinese Acad Med Sci, Fuwai Hosp, Beijing 100037, Peoples R China

[17] Peking Union Med Coll, Beijing 100021, Peoples R China

[18] Chinese Natl Ctr Cardiovasc Dis, Beijing, Peoples R China

[19] Natl Cerebral & Cardiovasc Ctr, Dept Prevent Cardiol, Suita, Osaka, Japan

[20] Chinese Natl Human Genom Ctr, Dept Genet, Shanghai, Peoples R China

[21] Kyushu Univ, Grad Sch Med Sci, Dept Geriatr Med, Fukuoka 812, Japan

[22] Mukogawa Womens Univ, Inst World Hlth Dev, Nishinomiya, Hyogo, Japan

[23] Nagoya Univ, Grad Sch Med, Dept Internal Med, Div Endocrinol & Diabet, Nagoya, Aichi 4648601, Japan

[24] Chubu Rosai Hosp, Dept Endocrinol & Diabet, Nagoya, Aichi, Japan

[25] NHLBI, Div Cardiovasc Sci, NIH, Bethesda, MD 20892 USA

[26] Univ Calif San Francisco, Inst Human Genet, San Francisco, CA 94143 USA

[27] Univ Texas Houston, Sch Publ Hlth, Dept Epidemiol, Houston, TX USA

[28] Ehime Univ, Grad Sch Med, Dept Geriatr Med, Toon, Japan

[29] Tsinghua Univ, Dept Automat, Key Lab Bioinformat, Beijing 100084, Peoples R China

[30] Asahi Life Fdn, Inst Adult Dis, Tokyo, Japan

[31] Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore

[32] Kyushu Univ, Grad Sch Med Sci, Dept Med & Bioregulatory Sci, Fukuoka 812, Japan

[33] Natl Univ Singapore, Dept Ophthalmol, Singapore 117548, Singapore

[34] Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA

[35] Univ Melbourne, Ctr Eye Res Australia, Melbourne, Vic, Australia

[36] Shimane Univ Hosp, Izumo, Shimane, Japan

[37] Osaka Univ, Grad Sch Med, Dept Geriatr Med & Nephrol, Suita, Osaka, Japan

[38] Natl Cerebral & Cardiovasc Ctr, Dept Genom Med, Suita, Osaka, Japan

[39] Natl Univ Singapore, Dept Stat & Appl Probabil, Singapore 117548, Singapore

[40] Natl Univ Singapore, Dept Epidemiol & Publ Hlth, Singapore 117548, Singapore

[41] Natl Univ Singapore, Dept Med, Singapore 117548, Singapore

[42] Tulane Univ, Sch Med, Dept Med, New Orleans, LA 70112 USA

[43] Natl Ctr Global Hlth & Med, Dept Gene Diagnost & Therapeut, Res Inst, Tokyo, Japan

来源：

NATURE GENETICS | 2011年 / 43卷 / 06期

基金：

英国医学研究理事会; 美国国家卫生研究院; 新加坡国家研究基金会;

关键词：

GENETIC-BASIS; POSITIVE SELECTION; GLOBAL BURDEN; WILL UNLOCK; HYPERTENSION; LOCI; RISK; ANNOTATION; PARAMETERS; IMPUTATION;

D O I：

10.1038/ng.834

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We conducted a meta-analysis of genome-wide association studies of systolic (SBP) and diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry from the AGEN-BP consortium followed up with de novo genotyping (n = 10,518) and further replication (n = 20,247) in east Asian samples. We identified genome-wide significant (P < 5 x 10(-8)) associations with SBP or DBP, which included variants at four new loci (ST7L-CAPZA1, FIGN-GRB14, ENPEP and NPR3) and a newly discovered variant near TBX3. Among the five newly discovered variants, we obtained significant replication in the independent samples for all of these loci except NPR3. We also confirmed seven loci previously identified in populations of European descent. Moreover, at 12q24.13 near ALDH2, we observed strong association signals (P = 7.9 x 10(-31) and P = 1.3 x 10(-35) for SBP and DBP, respectively) with ethnic specificity. These findings provide new insights into blood pressure regulation and potential targets for intervention.

引用

页码：530 / U57

页数：10

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