Regulation of dendritic cell recruitment by chemokines

被引：86

作者：

Caux, C ^{[1
]}

Vandervliet, B ^{[1
]}

Massacrier, C ^{[1
]}

Ait-Yahia, S ^{[1
]}

Vaure, C ^{[1
]}

Chemin, K ^{[1
]}

Dieu-Nosjean, MC ^{[1
]}

Vicari, A ^{[1
]}

机构：

[1] Schering Plough Corp, Lab Immunol Res, F-69571 Dardilly, France

来源：

TRANSPLANTATION | 2002年 / 73卷 / 01期

关键词：

D O I：

10.1097/00007890-200201151-00005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DC) are a heterogeneous family of cells that function as sentinels of the immune system. This article summarizes observations suggesting that inflammatory chemokines secreted at the site of pathogen invasion determine the DC subset recruited and influence the class of the immune response initiated. Langerhans cells are selectively recruited by MIP-3alpha/CCL20. In contrast, CCR7 ligands have a key role in the accumulation of antigen-loaded mature DC in T cell-rich areas of the draining lymph node. Improved understanding of the regulation of DC trafficking might offer new opportunities for therapeutic interventions to control immune responses.

引用

页码：S7 / S11

页数：5

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