Mechanisms of brain injury after global cerebral ischemia

被引：276

作者：

Harukuni, I

Bhardwaj, A

机构：

[1] Johns Hopkins Univ, Sch Med, Neurosci Crit Care Div, Dept Neurol,Johns Hopkins Hosp, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Sch Med, Div Cardiac Anesthesiol,Johns Hopkins Hosp, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21287 USA

[3] Johns Hopkins Univ, Sch Med, Neurosci Crit Care Div,Johns Hopkins Hosp, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21287 USA

来源：

NEUROLOGIC CLINICS | 2006年 / 24卷 / 01期

关键词：

D O I：

10.1016/j.ncl.2005.10.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Global cerebral ischemia occurs commonly in patients who have a variety of clinical conditions including cardiac arrest, shock, and asphyxia and in patients undergoing complex cardiac surgery. Irrespective of the etiology of cerebral ischemia, cellular and molecular processes trigger a cascade of events that culminates in a "final common pathway," resulting in ischemic neuronal injury. Identification of these injury mediators and pathways in a variety of experimental animal models of global cerebral ischemia has led to investigation of target-specific cytoprotective strategies that are critical to clinical brain injury outcome.

引用

页码：1 / +

页数：22

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