PROTECTION OF RAT HIPPOCAMPUS AGAINST ISCHEMIC NEURONAL DAMAGE BY PRETREATMENT WITH SUBLETHAL ISCHEMIA

被引：225

作者：

LIU, Y

KATO, H

NAKATA, N

KOGURE, K

机构：

[1] Department of Neurology, Institute of Brain Diseases, Tohoku University School of Medicine, SendaiJapan

来源：

BRAIN RESEARCH | 1992年 / 586卷 / 01期

关键词：

CEREBRAL ISCHEMIA; HIPPOCAMPUS; ISCHEMIC BRAIN DAMAGE; HEAT SHOCK PROTEIN; TOLERANCE; STRESS RESPONSE; RAT;

D O I：

10.1016/0006-8993(92)91380-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined whether preconditioning with sublethal ischemia protects against neuronal damage following subsequent lethal ischemic insults. Forebrain ischemia for 3 min in Wistar rats increased heat shock protein-70 immunoreactivity in the hippocampal CA1 subfield but produced no neuronal damage. Preconditioning with 3 min of ischemia followed by 3 days of reperfusion protected against hippocampal CA1 neuronal damage following 6 and 8 min of ischemia but not damage after 10 min of ischemia. The result strongly suggests that stress response induced by sublethal ischemia protects against ischemic brain damage.

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收藏

页码：121 / 124

页数：4

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