HYPERTHERMIA-INDUCED NEURONAL PROTECTION AGAINST ISCHEMIC-INJURY IN GERBILS

被引：121

作者：

KITAGAWA, K ^{[1
]}

MATSUMOTO, M ^{[1
]}

TAGAYA, M ^{[1
]}

KUWABARA, K ^{[1
]}

HATA, R ^{[1
]}

HANDA, N ^{[1
]}

FUKUNAGA, R ^{[1
]}

KIMURA, K ^{[1
]}

KAMADA, T ^{[1
]}

机构：

[1] OSAKA UNIV,SCH MED,BIOMED RES CTR,OSAKA 553,JAPAN

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 1991年 / 11卷 / 03期

关键词：

GERBIL; CEREBRAL ISCHEMIA; DELAYED NEURONAL DEATH; HYPERTHERMIA;

D O I：

10.1038/jcbfm.1991.86

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated the effect of hyperthermic pretreatment before induction of ischemia using a gerbil model of 5-min forebrain ischemia. A single hyperthermic treatment 18 h before ischemia exhibited a partial protective effect, and repetitive hyperthermic pretreatments at 18-h intervals before ischemia showed clear protection against neuronal death in the CA1 area of the hippocampus, whereas single hyperthermic treatment 3, 6, 24, or 50 h before ischemia exhibited little protective effect. This transient and cumulative neuroprotective effect of hyperthermic pretreatment strongly suggested the involvement of stress reactions after hyperthermia in the protective mechanism against ischemic neuronal death.

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收藏

页码：449 / 452

页数：4

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