SMART 6: recent updates and new developments

被引：790

作者：

Letunic, Ivica ^{[1
]}

Doerks, Tobias ^{[1
]}

Bork, Peer ^{[1
]}

机构：

[1] EMBL, D-69012 Heidelberg, Germany

来源：

NUCLEIC ACIDS RESEARCH | 2009年 / 37卷

关键词：

PROTEIN; GENOMES;

D O I：

10.1093/nar/gkn808

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Simple modular architecture research tool (SMART) is an online tool (http://smart.embl.de/) for the identification and annotation of protein domains. It provides a user-friendly platform for the exploration and comparative study of domain architectures in both proteins and genes. The current release of SMART contains manually curated models for 784 protein domains. Recent developments were focused on further data integration and improving user friendliness. The underlying protein database based on completely sequenced genomes was greatly expanded and now includes 630 species, compared to 191 in the previous release. As an initial step towards integrating information on biological pathways into SMART, our domain annotations were extended with data on metabolic pathways and links to several pathways resources. The interaction network view was completely redesigned and is now available for more than 2 million proteins. In addition to the standard web access to the database, users can now query SMART using distributed annotation system (DAS) or through a simple object access protocol (SOAP) based web service.

引用

页码：D229 / D232

页数：4

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