Long-term depression in hippocampus

被引：473

作者：

Bear, MF

Abraham, WC

机构：

[1] BROWN UNIV,HOWARD HUGHES MED INST,PROVIDENCE,RI 02912

[2] UNIV OTAGO,DEPT PSYCHOL,DUNEDIN,NEW ZEALAND

[3] UNIV OTAGO,NEUROSCI RES CTR,DUNEDIN,NEW ZEALAND

来源：

ANNUAL REVIEW OF NEUROSCIENCE | 1996年 / 19卷

关键词：

long-term potentiation; synaptic plasticity; learning and memory; calcium;

D O I：

10.1146/annurev.ne.19.030196.002253

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Long-term depression (LTD) is a lasting decrease in synaptic effectiveness that follows some types of electrical stimulation in the hippocampus. Two broad types of LTD may be distinguished. Heterosynaptic LTD can occur at synapses that are inactive, normally during high-frequency stimulation of a converging synaptic input. Homosynaptic LTD can occur at synapses that are activated, normally at low frequencies. Here we discuss the mechanisms of LTD and their possible relevance to hippocampal function.

引用

页码：437 / 462

页数：26

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