CESIUM PREVENTS MAINTENANCE OF LONG-TERM DEPRESSION IN RAT HIPPOCAMPAL CA1 NEURONS

被引：14

作者：

MACCAFERRI, G ^{[1
]}

JANIGRO, D ^{[1
]}

LAZZARI, A ^{[1
]}

DIFRANCESCO, D ^{[1
]}

机构：

[1] UNIV WASHINGTON,HARBORVIEW MED CTR,DEPT NEUROL SURG ZX18,SEATTLE,WA 98104

来源：

NEUROREPORT | 1994年 / 5卷 / 14期

关键词：

LONG-TERM DEPRESSION; HYPERPOLARIZATION-ACTIVATED CURRENT; HIPPOCAMPUS; NMDA-RECEPTOR;

D O I：

10.1097/00001756-199409080-00032

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

LONG-TERM depression of field excitatory postsynaptic potentials (EPSP) in the CA1 region of hippocampal slices was evoked by delivering a 15 min train of pulses at 1 Hz to the Schaffer-commissural-CA1 pathway, and prevented by adding an N-methyl-D-aspartate (NMDA) receptor antagonist (AP-5, 50 mu M) to the perfusing medium. Superfusion of the slices with Cs (2 mM) during the 1 Hz stimulation period could both inhibit the maintenance phase of the depression itself and elicit spontaneous rhythmic activity. Cs had no effect on the postsynaptic response to the GABA-B agonist, baclofen. As a major effect of Cs is a block of the hyperpolarization-activated current (I-h), these results suggest the possible involvement of I-h in the maintenance of long-term depression.

引用

页码：1813 / 1816

页数：4

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