VARIANT CYTOCHROME-P450 CYP2D6 ALLELIC FREQUENCIES IN PARKINSONS-DISEASE

被引：85

作者：

KURTH, MC

KURTH, JH

机构：

[1] Division of Neurology, Barrow Neurological Institute, Phoenix, AZ 85013

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS | 1993年 / 48卷 / 03期

关键词：

GENETICS; NEURODEGENERATIVE DISEASE; OXIDATIVE METABOLISM; LIVER ENZYMES; MOVEMENT DISORDERS;

D O I：

10.1002/ajmg.1320480311

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Aberrant detoxification of environmental agents may be the basis for an inherited predisposition to Parkinson's disease. A CYP2D6 genetic marker of the debrisoquine hydroxylase ''poor metabolizer'' phenotype was found to be significantly increased in Parkinson's disease patients compared to controls, as has been shown in previous studies. Presence of this marker gives an odds ratio of 1.86 for Parkinson's disease (95% confidence interval 1.33-2.39, P< 0.02). For comparison, a CYP1A1 polymorphism, which is not known to be associated with aberrant drug metabolism, showed no association with Parkinson's disease in our study. (C) 1993 Wiley-Liss, Inc.

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页码：166 / 168

页数：3

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