MUTANT DEBRISOQUINE HYDROXYLATION GENES IN PARKINSONS-DISEASE

被引：245

作者：

ARMSTRONG, M

DALY, AK

CHOLERTON, S

BATEMAN, DN

IDLE, JR

机构：

[1] MED SCH NEWCASTLE UPON TYNE,DEPT PHARMACOL SCI,PHARMACOGENET RES UNIT,FRAMLINGTON PL,NEWCASTLE TYNE NE2 4HH,ENGLAND

[2] MED SCH NEWCASTLE UPON TYNE,WOLFSON UNIT CLIN PHARMACOL,NEWCASTLE TYNE NE2 4HH,ENGLAND

来源：

LANCET | 1992年 / 339卷 / 8800期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0140-6736(92)90537-D

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The frequency of fifteen genotypes of CYP2D6 (debrisoquine 4-hydroxylase) in 53 patients with Parkinson's disease was determined by the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analyses and compared with the findings in 72 healthy controls. The commonest mutant allele, CYP2D6B, was twice as frequent among patients as in controls, with an approximate relative risk ratio of 2.70 (95% confidence interval 1.14-6.41; p = 0.0063) for subjects homozygous or heterozygous for this allele.

引用

页码：1017 / 1018

页数：2

共 10 条

[1]

BARBEAU A, 1985, LANCET, V2, P1213

[2] OXIDATIVE POLYMORPHISM OF DEBRISOQUINE IN PARKINSONS-DISEASE [J].

BENITEZ, J ;

LADERO, JM ;

JIMENEZJIMENEZ, FJ ;

MARTINEZ, C ;

PUERTO, AM ;

VALDIVIELSO, MJ ;

LLERENA, A ;

COBALEDA, J ;

MUNOZ, JJ .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1990, 53 (04) :289-292

[3] ETIOLOGY OF PARKINSONS-DISEASE [J].

CALNE, DB ;

LANGSTON, JW .

LANCET, 1983, 2 (8365) :1457-1459

[4] GENETIC AND METABOLIC CRITERIA FOR THE ASSIGNMENT OF DEBRISOQUINE 4-HYDROXYLATION (CYTOCHROME-P4502D6) PHENOTYPES [J].

DALY, AK ;

ARMSTRONG, M ;

MONKMAN, SC ;

IDLE, ME ;

IDLE, JR .

PHARMACOGENETICS, 1991, 1 (01) :33-41

[5] MPTP, THE NEUROTOXIN INDUCING PARKINSONS-DISEASE, IS A POTENT COMPETITIVE INHIBITOR OF HUMAN AND RAT CYTOCHROME-P450 ISOZYMES (P450BUFI, P450DB1) CATALYZING DEBRISOQUINE 4-HYDROXYLATION [J].

FONNEPFISTER, R ;

BARGETZI, MJ ;

MEYER, UA .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 148 (03) :1144-1150

[6] METABOLISM AND BRAIN ACCUMULATION OF TETRAHYDROISOQUINOLINE (TIQ) A POSSIBLE PARKINSONISM INDUCING SUBSTANCE, IN AN ANIMAL-MODEL OF A POOR DEBRISOQUINE METABOLIZER [J].

OHTA, S ;

TACHIKAWA, O ;

MAKINO, Y ;

TASAKI, Y ;

HIROBE, M .

LIFE SCIENCES, 1990, 46 (08) :599-605

[7]

POIRIER J, 1987, LANCET, V2, P386

[8] ENVIRONMENTAL-FACTORS IN THE ETIOLOGY OF PARKINSONS-DISEASE [J].

TANNER, CM ;

CHEN, B ;

WANG, WZ ;

PENG, ML ;

LIU, ZL ;

LIANG, XL ;

KAO, LC ;

GILLEY, DW ;

SCHOENBERG, BS .

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 1987, 14 (03) :419-423

[9] IDENTIFICATION OF A NEW VARIANT CYP2D6 ALLELE LACKING THE CODON ENCODING LYS-281 - POSSIBLE ASSOCIATION WITH THE POOR METABOLIZER PHENOTYPE [J].

TYNDALE, R ;

AOYAMA, T ;

BROLY, F ;

MATSUNAGA, T ;

INABA, T ;

KALOW, W ;

GELBOIN, HV ;

MEYER, UA ;

GONZALEZ, FJ .

PHARMACOGENETICS, 1991, 1 (01) :26-32

[10]

TYNDALE RF, 1991, MOL PHARMACOL, V40, P63

← 1 →