ABNORMAL LIVER ENZYME-MEDIATED METABOLISM IN PARKINSONS-DISEASE - A 2ND LOOK

If toxicant exposure contributes to the cause of Parkinson's disease, poor function of detroxifying enzymes could increase vulnerability for Parkinson's disease patients, several have been suggested to be dysfunctional in subgroups, such as those with young age at disease onset. Specific enzymes implicated include several P450 enzymes, most notably P450 IID6, and cysteine dioxygenase. If hepatic enzyme abnormalities contribute to the development of Parkinson's disease, molecular genetic techniques may allow the development of screening tests to identify at-risk subjects in order to intervene with protective therapies.