EVIDENCE FOR AN ENZYMATIC DEFECT IN THE 4-HYDROXYLATION OF DEBRISOQUINE BY HUMAN-LIVER

被引：111

作者：

DAVIES, DS

KAHN, GC

MURRAY, S

BRODIE, MJ

BOOBIS, AR

机构：

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1981年 / 11卷 / 01期

关键词：

D O I：

10.1111/j.1365-2125.1981.tb01108.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：89 / 91

页数：3

共 11 条

[1] PHARMACOGENETIC COVARIATION OF DEFECTIVE N-OXIDATION OF SPARTEINE AND 4-HYDROXYLATION OF DEBRISOQUINE [J].

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EICHELBAUM, M ;

SCHULZ, HU .

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[2] MONO-OXYGENASE ACTIVITY OF HUMAN-LIVER IN MICROSOMAL FRACTIONS OF NEEDLE-BIOPSY SPECIMENS [J].

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BRODIE, MJ ;

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[3]

BOOBIS AR, 1979, BRIT J PHARMACOL, V66, pP428

[4]

EICHELBAUM M, 1975, THESIS U BONN W GERM

[5] DEFICIENT METABOLISM OF DEBRISOQUINE AND SPARTEINE [J].

INABA, T ;

OTTON, SV ;

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CLINICAL PHARMACOLOGY & THERAPEUTICS, 1980, 27 (04) :547-549

[6] POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN [J].

MAHGOUB, A ;

IDLE, JR ;

DRING, LG ;

LANCASTER, R ;

SMITH, RL .

LANCET, 1977, 2 (8038) :584-586

[7] DETERMINATION OF DEBRISOQUIN AND ITS 4-HYDROXY METABOLITE IN PLASMA BY GAS CHROMATOGRAPHY MASS SPECTROMETRY [J].

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MARTEN, TR .

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[8]

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[9]

Ritchie J. C., 1980, ENV CHEM ENZYME FUNC, P219

[10] POLYMORPHISM OF CARBON OXIDATION OF DRUGS AND CLINICAL IMPLICATIONS [J].

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IDLE, JR ;

SMITH, RL .

BRITISH MEDICAL JOURNAL, 1978, 2 (6138) :655-657

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