PHARMACOGENETIC COVARIATION OF DEFECTIVE N-OXIDATION OF SPARTEINE AND 4-HYDROXYLATION OF DEBRISOQUINE

被引：83

作者：

BERTILSSON, L

DENGLER, HJ

EICHELBAUM, M

SCHULZ, HU

机构：

[1] UNIV BONN,DEPT MED,D-5300 BONN 1,FED REP GER

[2] HUDDINGE HOSP,KAROLINSKA INST,DEPT CLIN PHARMACOL,S-14186 HUDDINGE,SWEDEN

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1980年 / 17卷 / 02期

关键词：

D O I：

10.1007/BF00562624

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：153 / 155

页数：3

共 9 条

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[2] DEFECTIVE N-OXIDATION OF SPARTEINE IN MAN - NEW PHARMACOGENETIC DEFECT [J].

EICHELBAUM, M ;

SPANNBRUCKER, N ;

STEINCKE, B ;

DENGLER, HJ .

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[3]

Eichelbaum M, 1975, 6TH INT C PHARM HELS, P1071

[4]

EICHELBAUM M, 1975, THESIS U BONN

[5] HYPOTENSIVE RESPONSE TO DEBRISOQUINE AND HYDROXYLATION PHENOTYPE [J].

IDLE, JR ;

MAHGOUB, A ;

LANCASTER, R ;

SMITH, RL .

LIFE SCIENCES, 1978, 22 (11) :979-983

[6] DETERMINATION OF DEBRISOQUINE AND ITS 4-HYDROXY METABOLITE IN BIOLOGICAL-FLUIDS BY GAS-CHROMATOGRAPHY WITH FLAME-IONIZATION AND NITROGEN-SELECTIVE DETECTION [J].

LENNARD, MS ;

SILAS, JH ;

SMITH, AJ ;

TUCKER, GT .

JOURNAL OF CHROMATOGRAPHY, 1977, 133 (01) :161-166

[7] POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN [J].

MAHGOUB, A ;

IDLE, JR ;

DRING, LG ;

LANCASTER, R ;

SMITH, RL .

LANCET, 1977, 2 (8038) :584-586

[8]

MITCHELL JR, 1970, J PHARMACOL EXP THER, V172, P108

[9]

SJOQVIST F, 1980, DRUG TREATMENT, P1

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