ORGANIZATION AND FUNCTION OF THE CYTOSKELETON IN POLARIZED EPITHELIAL-CELLS - A COMPONENT OF THE PROTEIN SORTING MACHINERY

被引：137

作者：

MAYS, RW

BECK, KA

NELSON, WJ

机构：

[1] Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford

来源：

CURRENT OPINION IN CELL BIOLOGY | 1994年 / 6卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0955-0674(94)90111-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Development and maintenance of cell-surface polarity in epithelial cells requires specialized localization of proteins to functionally and structurally distinct plasma membrane domains. The organization of these domains is dependent upon targeted delivery of transport vesicles between different membrane compartments, and upon protein sorting in the membranes of the Golgi complex and cell surface. Increasing evidence has been gathered in recent years that cytoskeletal components facilitate these processes.

引用

页码：16 / 24

页数：9

共 85 条

[71] MICROTUBULES AND ACTIN-FILAMENTS ARE NOT CRITICALLY INVOLVED IN THE BIOGENESIS OF EPITHELIAL-CELL SURFACE POLARITY [J].