COMBINATORIAL RNA SPLICING ALTERS THE SURFACE-CHARGE ON THE NMDA RECEPTOR

被引：111

作者：

ANANTHARAM, V

PANCHAL, RG

WILSON, A

KOLCHINE, VV

TREISTMAN, SN

BAYLEY, H

机构：

[1] WORCESTER FDN EXPTL BIOL INC, 222 MAPLE AVE, SHREWSBURY, MA 01545 USA

[2] UNIV MASSACHUSETTS, MED CTR, DEPT PHARMACOL, WORCESTER, MA 01655 USA

来源：

FEBS LETTERS | 1992年 / 305卷 / 01期

关键词：

RECEPTOR; CHANNEL; EXCITATORY AMINO ACID; GLUTAMATE; RNA SPLICING;

D O I：

10.1016/0014-5793(92)80648-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transcripts encoding four NMDA receptor subunits, generated from the NMDAR1 gene by alternative RNA splicing, have been demonstrated in adult rat brain. RNA transcripts derived from cDNAs encoding each form direct the formation of functional NMDA receptors in Xenopus oocytes. The two amino acid cassettes of 21 and 37 amino acids found in the splice variants increase the positive extracellular surface charge on the subunits and may thereby modulate the functional properties of the receptor.

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页码：27 / 30

页数：4

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共 21 条

[11] ETHANOL INHIBITS NMDA-ACTIVATED ION CURRENT IN HIPPOCAMPAL-NEURONS [J].

LOVINGER, DM ;

WHITE, G ;

WEIGHT, FF .

SCIENCE, 1989, 243 (4899) :1721-1724

[12] EXCITATORY AMINO-ACID NEUROTOXICITY AND NEURODEGENERATIVE DISEASE [J].

MELDRUM, B ;

GARTHWAITE, J .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1990, 11 (09) :379-387

[13] MOLECULAR-CLONING AND CHARACTERIZATION OF THE RAT NMDA RECEPTOR [J].

MORIYOSHI, K ;

MASU, M ;

ISHII, T ;

SHIGEMOTO, R ;

MIZUNO, N ;

NAKANISHI, S .

NATURE, 1991, 354 (6348) :31-37

[14] A FAMILY OF GLUTAMATE RECEPTOR GENES - EVIDENCE FOR THE FORMATION OF HETEROMULTIMERIC RECEPTORS WITH DISTINCT CHANNEL PROPERTIES [J].

NAKANISHI, N ;

SHNEIDER, NA ;

AXEL, R .

NEURON, 1990, 5 (05) :569-581

[15] FUNCTIONAL COMPARISON OF NEUROTRANSMITTER RECEPTOR SUBTYPES IN MAMMALIAN CENTRAL-NERVOUS-SYSTEM [J].

NICOLL, RA ;

MALENKA, RC ;

KAUER, JA .

PHYSIOLOGICAL REVIEWS, 1990, 70 (02) :513-565

[16] PHOSPHORYLATION AFFECTS VOLTAGE GATING OF THE DELAYED RECTIFIER K+ CHANNEL BY ELECTROSTATIC INTERACTIONS [J].

PEROZO, E ;

BEZANILLA, F .

NEURON, 1990, 5 (05) :685-690

[17] NEURAMINIDASE TREATMENT MODIFIES THE FUNCTION OF ELECTROPLAX SODIUM-CHANNELS IN PLANAR LIPID BILAYERS [J].

RECIOPINTO, E ;

THORNHILL, WB ;

DUCH, DS ;

LEVINSON, SR ;

URBAN, BW .

NEURON, 1990, 5 (05) :675-684

[18] ALTERNATIVE SPLICING IN THE CONTROL OF GENE-EXPRESSION [J].

SMITH, CWJ ;

PATTON, JG ;

NADALGINARD, B .

ANNUAL REVIEW OF GENETICS, 1989, 23 :527-577

[19] NICOTINIC ACETYLCHOLINE-RECEPTOR SUPERFAMILY OF LIGAND-GATED ION CHANNELS [J].

STROUD, RM ;

MCCARTHY, MP ;

SHUSTER, M .

BIOCHEMISTRY, 1990, 29 (50) :11009-11023

[20] CLONING OF A PUTATIVE HIGH-AFFINITY KAINATE RECEPTOR EXPRESSED PREDOMINANTLY IN HIPPOCAMPAL CA3 CELLS [J].

WERNER, P ;

VOIGT, M ;

KEINANEN, K ;

WISDEN, W ;

SEEBURG, PH .

NATURE, 1991, 351 (6329) :742-744