MOLECULAR-CLONING AND CHARACTERIZATION OF THE RAT NMDA RECEPTOR

被引：1712

作者：

MORIYOSHI, K ^{[1
]}

MASU, M ^{[1
]}

ISHII, T ^{[1
]}

SHIGEMOTO, R ^{[1
]}

MIZUNO, N ^{[1
]}

NAKANISHI, S ^{[1
]}

机构：

[1] KYOTO UNIV,DEPT MORPHOL BRAIN SCI,KYOTO 606,JAPAN

来源：

NATURE | 1991年 / 354卷 / 6348期

关键词：

D O I：

10.1038/354031a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A complementary DNA encoding the rat NMDA receptor has been cloned and characterized. The single protein encoded by the cDNA forms a receptor-channel complex that has electrophysiological and pharmacological properties characteristic of the NMDA receptor. This protein has a significant sequence similarity to the AMPA/kainate receptors and contains four putative transmembrane segments following a large extracellular domain. The NMDA receptor messenger RNA is expressed in neuronal cells throughout the brain regions, particularly in the hippocampus, cerebral cortex and cerebellum.

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页码：31 / 37

页数：7

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