CD44 SPLICE VARIANTS - METASTASES MEET LYMPHOCYTES

被引：279

作者：

HERRLICH, P

ZOLLER, M

PALS, ST

PONTA, H

机构：

来源：

IMMUNOLOGY TODAY | 1993年 / 14卷 / 08期

关键词：

D O I：

10.1016/0167-5699(93)90141-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent discoveries of surface proteins involved in tumor metastasis formation have revived an old hypothesis that tumor cells may acquire, and use for their metastatic spreading, properties which lymphoid cells had developed to defend the organism against foreign antigens. Splice variants of CD44 and integrins are expressed on metastasizing tumor cells and also on leukocytes at defined stages of their differentiation. Expression and function appear to be essential not only for the generation of an immune response but also for the establishment of metastatic tumor colonies.

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页码：395 / 399

页数：5

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