DIFFERENTIAL SUBCELLULAR-DISTRIBUTION OF THE ALPHA-6 SUBUNIT VERSUS THE ALPHA-1 AND BETA-2/3 SUBUNITS OF THE GABAA/BENZODIAZEPINE RECEPTOR COMPLEX IN GRANULE CELLS OF THE CEREBELLAR CORTEX

被引：99

作者：

BAUDE, A ^{[1
]}

SEQUIER, JM ^{[1
]}

MCKERNAN, RM ^{[1
]}

OLIVIER, KR ^{[1
]}

SOMOGYI, P ^{[1
]}

机构：

[1] MERCK SHARP & DOHME LTD, NEUROSCI RES CTR, DEPT BIOCHEM, HARLOW CM20 2QR, ENGLAND

来源：

NEUROSCIENCE | 1992年 / 51卷 / 04期

关键词：

D O I：

10.1016/0306-4522(92)90513-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The distribution of the alpha6 subunit of the GABA(A) receptor has been established in rat cerebellum and compared to the distribution of the alpha1 (cat) and the beta2/3 (rat, cat) subunits, using immunocytochemistry. The synapses established by Golgi cell terminals on the dendrites of granule cells were immunoreactive for the alpha6, alpha1 and beta2/3 subunits in virtually all glomeruli, indicating that two variants (alpha1 and alpha6) of the same subunit are co-localized at the same synapses. The somatic membranes of the granule cells, which receive no synapses, were immunopositive for the alpha1 and beta2/3 subunits, but not for the alpha6 subunit. Thus, the alpha1 and the beta2/3 subunits are located at both synaptic and extrasynaptic sites, but the alpha6 subunit is detectable only at synaptic sites.

引用

页码：739 / 748

页数：10

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