REGULATION OF THE BETA-GLOBIN LOCUS

被引：87

作者：

CROSSLEY, M

ORKIN, SH

机构：

[1] HOWARD HUGHES MED INST, BOSTON, MA USA

[2] HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1993年 / 3卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0959-437X(93)90028-N

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Transcription of the human beta-globin gene cluster depends upon upstream regulatory sequences, which are collectively termed the locus control region. Recent studies have provided new insights into how the individual genes of the cluster are regulated through development. The crux of transcriptional activation is how the locus control region communicates with the gene-proximal regulatory elements.

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收藏

页码：232 / 237

页数：6

相关论文

共 40 条

[1]

ANDREWS NC, 1993, IN PRESS NATURE

[2] HUMAN GAMMA-GLOBIN TO BETA-GLOBIN GENE SWITCHING IN TRANSGENIC MICE [J].

BEHRINGER, RR ;

RYAN, TM ;

PALMITER, RD ;

BRINSTER, RL ;

TOWNES, TM .

GENES & DEVELOPMENT, 1990, 4 (03) :380-389

[3] A SINGLE POINT MUTATION IS THE CAUSE OF THE GREEK FORM OF HEREDITARY PERSISTENCE OF FETAL HEMOGLOBIN [J].

BERRY, M ;

GROSVELD, F ;

DILLON, N .

NATURE, 1992, 358 (6386) :499-502

[4] DEVELOPMENTAL REGULATION OF BETA-GLOBIN GENE SWITCHING [J].

CHOI, ORB ;

ENGEL, JD .

CELL, 1988, 55 (01) :17-26

[5] HUMAN GAMMA-GLOBIN GENES SILENCED INDEPENDENTLY OF OTHER GENES IN THE BETA-GLOBIN LOCUS [J].

DILLON, N ;

GROSVELD, F .

NATURE, 1991, 350 (6315) :252-254

[6] DEVELOPMENTAL REGULATION OF HUMAN FETAL-TO-ADULT GLOBIN GENE SWITCHING IN TRANSGENIC MICE [J].

ENVER, T ;

RAICH, N ;

EBENS, AJ ;

PAPAYANNOPOULOU, T ;

COSTANTINI, F ;

STAMATOYANNOPOULOS, G .

NATURE, 1990, 344 (6264) :309-313

[7] CHROMATIN AS AN ESSENTIAL PART OF THE TRANSCRIPTIONAL MECHANISM [J].

FELSENFELD, G .

NATURE, 1992, 355 (6357) :219-224

[8] INDIVIDUAL STAGE SELECTOR ELEMENT MUTATIONS LEAD TO RECIPROCAL CHANGES IN BETA-GLOBIN VS EPSILON-GLOBIN GENE-TRANSCRIPTION - GENETIC CONFIRMATION OF PROMOTER COMPETITION DURING GLOBIN GENE SWITCHING [J].

FOLEY, KP ;

ENGEL, JD .

GENES & DEVELOPMENT, 1992, 6 (05) :730-744

[9] THE ERYTHROID-SPECIFIC PROTEIN CGATA-1 MEDIATES DISTAL ENHANCER ACTIVITY THROUGH A SPECIALIZED BETA-GLOBIN TATA BOX [J].

FONG, TC ;

EMERSON, BM .

GENES & DEVELOPMENT, 1992, 6 (04) :521-532

[10] EACH HYPERSENSITIVE SITE OF THE HUMAN BETA-GLOBIN LOCUS-CONTROL REGION CONFERS A DIFFERENT DEVELOPMENTAL PATTERN OF EXPRESSION ON THE GLOBIN GENES [J].

FRASER, P ;

PRUZINA, S ;

ANTONIOU, M ;

GROSVELD, F .

GENES & DEVELOPMENT, 1993, 7 (01) :106-113

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