DEVELOPMENTAL REGULATION OF HUMAN FETAL-TO-ADULT GLOBIN GENE SWITCHING IN TRANSGENIC MICE

被引：313

作者：

ENVER, T

RAICH, N

EBENS, AJ

PAPAYANNOPOULOU, T

COSTANTINI, F

STAMATOYANNOPOULOS, G

机构：

[1] UNIV WASHINGTON,DEPT MED,DIV HEMATOL,SEATTLE,WA 98195

[2] COLUMBIA UNIV COLL PHYS & SURG,DEPT GENET & DEV,NEW YORK,NY 10032

来源：

NATURE | 1990年 / 344卷 / 6264期

关键词：

D O I：

10.1038/344309a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Transgenic mice containing a human fetal (γ-) or adult (β-) globin gene linked to the β-globin gene locus activation region (LAR) express the gene throughout development. By contrast transgenic mice containing LAR linked to both a fetal and an adult globin gene display the normal developmental switch from fetal to adult gene expression. This suggests that the human fetal-to-adult globin gene switch is controlled through a mutually exclusive interaction between LAR and either the γ- or β-globin gene, resulting in the expression of only one gene at any given moment. © 1990 Nature Publishing Group.

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页码：309 / 313

页数：5

相关论文

共 33 条

[1]

[Anonymous], 1986, MANIPULATING MOUSE E

[2] RAPID REPROGRAMMING OF GLOBIN GENE-EXPRESSION IN TRANSIENT HETEROKARYONS [J].

BARON, MH ;

MANIATIS, T .

CELL, 1986, 46 (04) :591-602

[3] 2 3' SEQUENCES DIRECT ADULT ERYTHROID-SPECIFIC EXPRESSION OF HUMAN BETA-GLOBIN GENES IN TRANSGENIC MICE [J].

BEHRINGER, RR ;

HAMMER, RE ;

BRINSTER, RL ;

PALMITER, RD ;

TOWNES, TM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (20) :7056-7060

[4] AN EMBRYONIC PATTERN OF EXPRESSION OF A HUMAN-FETAL GLOBIN GENE IN TRANSGENIC MICE [J].

CHADA, K ;

MAGRAM, J ;

COSTANTINI, F .

NATURE, 1986, 319 (6055) :685-689

[5] DEVELOPMENTAL REGULATION OF BETA-GLOBIN GENE SWITCHING [J].

CHOI, ORB ;

ENGEL, JD .

CELL, 1988, 55 (01) :17-26

[6] DEVELOPMENTAL REGULATION OF HUMAN GLOBIN GENES IN TRANSGENIC MICE [J].

COSTANTINI, F ;

RADICE, G ;

MAGRAM, J ;

STAMATOYANNOPOULOS, G ;

PAPAYANNOPOULOU, T ;

CHADA, K .

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1985, 50 :361-370

[7]

CURTINPT, 1989, P NATL ACAD SCI USA, V86, P7083

[8] ERYTHROPOIETIN CHANGES THE GLOBIN PROGRAM OF AN INTERLEUKIN 3-DEPENDENT MULTIPOTENTIAL CELL-LINE [J].

ENVER, T ;

NAKAMOTO, B ;

KARLINSEY, J ;

JOSEPHSON, B ;

GREENBERGER, J ;

PAPAYANNOPOULOU, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (23) :9091-9095

[9] THE HUMAN BETA-GLOBIN LOCUS ACTIVATION REGION ALTERS THE DEVELOPMENTAL FATE OF A HUMAN-FETAL GLOBIN GENE IN TRANSGENIC MICE [J].

ENVER, T ;

EBENS, AJ ;

FORRESTER, WC ;

STAMATOYANNOPOULOS, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (18) :7033-7037

[10] MOLECULAR ANALYSIS OF THE HUMAN BETA-GLOBIN LOCUS ACTIVATION REGION [J].

FORRESTER, WC ;

NOVAK, U ;

GELINAS, R ;

GROUDINE, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (14) :5439-5443

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