CHROMATIN AS AN ESSENTIAL PART OF THE TRANSCRIPTIONAL MECHANISM

被引：827

作者：

FELSENFELD, G

机构：

[1] Laboratory of Molecular Biology, National Institutes of Health, Bethesda

来源：

NATURE | 1992年 / 355卷 / 6357期

关键词：

D O I：

10.1038/355219a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The increasingly detailed biochemical definition of the protein complexes that regulate gene transcription has led to the re-emergence of questions about the role of histones. Much recent evidence suggests that transcriptional activation requires that transcription factors successfully compete with histones for binding to promoters, and that there may be more than one mechanism by which this is achieved.

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页码：219 / 224

页数：6

相关论文

共 87 条

[1] PARTICIPATION OF CORE HISTONE TAILS IN THE STABILIZATION OF THE CHROMATIN SOLENOID [J].

ALLAN, J ;

HARBORNE, N ;

RAU, DC ;

GOULD, H .

JOURNAL OF CELL BIOLOGY, 1982, 93 (02) :285-297

[2] REMOVAL OF POSITIONED NUCLEOSOMES FROM THE YEAST PHO5 PROMOTER UPON PHO5 INDUCTION RELEASES ADDITIONAL UPSTREAM ACTIVATING DNA ELEMENTS [J].

ALMER, A ;

RUDOLPH, H ;

HINNEN, A ;

HORZ, W .

EMBO JOURNAL, 1986, 5 (10) :2689-2696

[3] NUCLEASE HYPERSENSITIVE REGIONS WITH ADJACENT POSITIONED NUCLEOSOMES MARK THE GENE BOUNDARIES OF THE PHO5/PHO3 LOCUS IN YEAST [J].

ALMER, A ;

HORZ, W .

EMBO JOURNAL, 1986, 5 (10) :2681-2687

[4] COMPETITION BETWEEN TRANSCRIPTION COMPLEX ASSEMBLY AND CHROMATIN ASSEMBLY ON REPLICATING DNA [J].

ALMOUZNI, G ;

MECHALI, M ;

WOLFFE, AP .

EMBO JOURNAL, 1990, 9 (02) :573-582

[5] RAPID REPROGRAMMING OF GLOBIN GENE-EXPRESSION IN TRANSIENT HETEROKARYONS [J].

BARON, MH ;

MANIATIS, T .

CELL, 1986, 46 (04) :591-602

[6] HEAT SHOCK-REGULATED TRANSCRIPTION INVITRO FROM A RECONSTITUTED CHROMATIN TEMPLATE [J].

BECKER, PB ;

RABINDRAN, SK ;

WU, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (10) :4109-4113

[7] DIFFERENTIATION REQUIRES CONTINUOUS REGULATION [J].

BLAU, HM ;

BALTIMORE, D .

JOURNAL OF CELL BIOLOGY, 1991, 112 (05) :781-783

[8] CYTOPLASMIC ACTIVATION OF HUMAN NUCLEAR GENES IN STABLE HETEROCARYONS [J].

BLAU, HM ;

CHIU, CP ;

WEBSTER, C .

CELL, 1983, 32 (04) :1171-1180

[9] STABLE TRANSCRIPTION COMPLEXES OF XENOPUS 5S RNA GENES - A MEANS TO MAINTAIN THE DIFFERENTIATED STATE [J].

BOGENHAGEN, DF ;

WORMINGTON, WM ;

BROWN, DD .

CELL, 1982, 28 (02) :413-421

[10] A MECHANISM FOR SYNERGISTIC ACTIVATION OF A MAMMALIAN GENE BY GAL4 DERIVATIVES [J].

CAREY, M ;

LIN, YS ;

GREEN, MR ;

PTASHNE, M .

NATURE, 1990, 345 (6273) :361-364

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