DIALECTICS IN CARRIER RESEARCH - THE ADP/ATP CARRIER AND THE UNCOUPLING PROTEIN

被引：92

作者：

KLINGENBERG, M

机构：

[1] Institute for Physical Biochemistry, University of Munich, München 2, W-8000

来源：

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES | 1993年 / 25卷 / 05期

关键词：

ADP/ATP CARRIER; UNCOUPLING PROTEIN; TRANSPORT; MITOCHONDRIA;

D O I：

10.1007/BF01108402

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A concise review is given of the research in our laboratory on the ADP/ATP carrier (AAC) and the uncoupling protein (UCP). Although homologous proteins, their widely different functions and contrasts are stressed. The pioneer role of research on the AAC, not only for the mitochondrial but also for other carriers, and the present state of their structure-function relationship is reviewed. The function of UCP as a highly regulated H+ carrier is described in contrast to the largely unregulated ADP/ATP exchange in AAC. General principles of carrier catalysis as derived from studies on the AAC and UCP are elucidated.

引用

页码：447 / 457

页数：11

共 68 条

[41]

KRAMER R, 1979, BIOCHEMISTRY-US, V18, P4209

[42]

KRAMER R, 1982, BIOCHEMISTRY-US, V21, P1082

[43]

KRAMER R, 1977, BIOCHEMISTRY-US, V16, P4954

[44]

KRAMER R, 1980, BIOCHEMISTRY-US, V19, P556

[45]

Krumer R., 1992, MOL MECHANISMS BIOEN, P359, DOI DOI 10.1016/50167-7306(08)60184-2

[46]

LANOUE K, 1978, J BIOL CHEM, V253, P191

[47] METABOLITE TRANSPORT IN MITOCHONDRIA [J].

LANOUE, KF ;

SCHOOLWERTH, AC .

ANNUAL REVIEW OF BIOCHEMISTRY, 1979, 48 :871-922

[48]

LAWSON JE, 1990, J BIOL CHEM, V265, P14195

[49]

LAWSON JE, 1988, J BIOL CHEM, V263, P14812

[50] THE UNCOUPLING PROTEIN FROM BROWN ADIPOSE-TISSUE MITOCHONDRIA IS A DIMER - A HYDRODYNAMIC STUDY [J].

LIN, CS ;

HACKENBERG, H ;

KLINGENBERG, EM .

FEBS LETTERS, 1980, 113 (02) :304-306

← 1 2 3 4 5 6 7 →