HUMAN CHRONIC LYMPHOCYTIC-LEUKEMIA CELLS REGULARLY EXPRESS MESSENGER-RNAS OF THE PROTOONCOGENES LCK AND C-FGR

被引：28

作者：

ABTS, H

JUCKER, M

DIEHL, V

TESCH, H

机构：

[1] I. Medizinische Klinik, Universität Köln, D-5000 Köln 41

来源：

LEUKEMIA RESEARCH | 1991年 / 15卷 / 11期

关键词：

ONCOGENE EXPRESSION; LCK; C-FGR; CHRONIC LYMPHOCYTIC LEUKEMIA; HUMAN B-LYMPHOCYTES; MAGNETIC CELL SEPARATION;

D O I：

10.1016/0145-2126(91)90103-Z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Protooncogenes, the cellular homologues of transforming retroviral oncogenes, have been suggested to participate in malignant transformation of various cell types. The role activated protooncogenes might play in chronic lymphocytic leukemia (CLL) is not yet clear. We investigated the expression of the protooncogenes lck and c-fgr encoding two protein tyrosine kinases by Northern-blot analysis in 21 patients with B-CLL and transcripts of both genes were detected in all cases. In contrast to CLL B cells, normal B cells from peripheral blood of a healthy donor separated by magnetic sorting did not express c-fgr and lck. The results suggest a possible role for these two protooncogenes of the src family in the activation and/or transformation of human B lymphocytes.

引用

页码：987 / &

共 39 条

[1] CD20 POSITIVE HUMAN LYMPHOCYTES-B SEPARATED WITH THE MAGNETIC CELL SORTER (MACS) CAN BE INDUCED TO PROLIFERATION AND ANTIBODY SECRETION INVITRO [J].