GABA-B AUTORECEPTORS REGULATE THE INDUCTION OF LTP

被引:498
作者
DAVIES, CH
STARKEY, SJ
POZZA, MF
COLLINGRIDGE, GL
机构
[1] UNIV BIRMINGHAM, SCH MED, DEPT INTERNAL MED, BIRMINGHAM B15 2TT, W MIDLANDS, ENGLAND
[2] UNIV BRISTOL, SCH MED SCI, DEPT PHARMACOL, BRISTOL BS8 1TD, AVON, ENGLAND
关键词
D O I
10.1038/349609a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
UNDERSTANDING the mechanisms involved in long-term potentiation (LTP) should provide insights into the cellular and molecular basis of learning and memory in vertebrates 1. It has been established that in the CA1 region of the hippocampus the induction of LTP requires the transient activation of the N-methyl-D-aspartate (NMDA) receptor system 21. During low-frequency transmission, significant activation of this system is prevented by gamma-aminobutyric acid (GABA) mediated synaptic inhibition 3,4 which hyperpolarizes neurons into a region where NMDA receptor-operated channels are substantially blocked by Mg2+ (refs. 5, 6). But during high-frequency transmission, mechanisms are evoked that provide sufficient depolarization of the postsynaptic membrane to reduce this block 7 and thereby permit the induction of LTP. We now report that this critical depolarization is enabled because during high-frequency transmission GABA depresses its own release by an action on GABA(B) autoreceptors, which permits sufficient NMDA receptor activation for the induction of LTP. These findings demonstrate a role for GABA(B) receptors in synaptic plasticity.
引用
收藏
页码:609 / 611
页数:3
相关论文
共 25 条
[11]   INVOLVEMENT OF N-METHYL-D-ASPARTATE RECEPTORS IN EPILEPTIFORM BURSTING IN THE RAT HIPPOCAMPAL SLICE [J].
DINGLEDINE, R ;
HYNES, MA ;
KING, GL .
JOURNAL OF PHYSIOLOGY-LONDON, 1986, 380 :175-189
[12]   PRE-SYNAPTIC AND POSTSYNAPTIC GABAB RECEPTORS IN THE HIPPOCAMPUS HAVE DIFFERENT PHARMACOLOGICAL PROPERTIES [J].
DUTAR, P ;
NICOLL, RA .
NEURON, 1988, 1 (07) :585-591
[13]   A PHYSIOLOGICAL-ROLE FOR GABAB RECEPTORS IN THE CENTRAL NERVOUS-SYSTEM [J].
DUTAR, P ;
NICOLL, RA .
NATURE, 1988, 332 (6160) :156-158
[14]   ON THE PRESYNAPTIC ACTION OF BACLOFEN AT INHIBITORY SYNAPSES BETWEEN CULTURED RAT HIPPOCAMPAL-NEURONS [J].
HARRISON, NL .
JOURNAL OF PHYSIOLOGY-LONDON, 1990, 422 :433-446
[15]   A PERSISTENT POSTSYNAPTIC MODIFICATION MEDIATES LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].
KAUER, JA ;
MALENKA, RC ;
NICOLL, RA .
NEURON, 1988, 1 (10) :911-917
[16]   BACLOFEN SELECTIVELY INHIBITS EXCITATORY SYNAPTIC TRANSMISSION IN THE HIPPOCAMPUS [J].
LANTHORN, TH ;
COTMAN, CW .
BRAIN RESEARCH, 1981, 225 (01) :171-178
[17]   ROLE OF N-METHYL-D-ASPARTATE RECEPTORS IN THE INDUCTION OF SYNAPTIC POTENTIATION BY BURST STIMULATION PATTERNED AFTER THE HIPPOCAMPAL O-RHYTHM [J].
LARSON, J ;
LYNCH, G .
BRAIN RESEARCH, 1988, 441 (1-2) :111-118
[18]   THE ACTION OF N-METHYL-D-ASPARTIC ACID ON MOUSE SPINAL NEURONS IN CULTURE [J].
MAYER, ML ;
WESTBROOK, GL .
JOURNAL OF PHYSIOLOGY-LONDON, 1985, 361 (APR) :65-90
[19]   USE-DEPENDENT DEPRESSION OF IPSPS IN RAT HIPPOCAMPAL PYRAMIDAL CELLS-INVITRO [J].
MCCARREN, M ;
ALGER, BE .
JOURNAL OF NEUROPHYSIOLOGY, 1985, 53 (02) :557-571
[20]   BACLOFEN FACILITATES THE DEVELOPMENT OF LONG-TERM POTENTIATION IN THE RAT DENTATE GYRUS [J].
MOTT, DD ;
LEWIS, DV ;
FERRARI, CM ;
WILSON, WA ;
SWARTZWELDER, HS .
NEUROSCIENCE LETTERS, 1990, 113 (02) :222-226