PRENATAL DETECTION OF GENETIC DEFECTS

The background and present knowledge of the prenatal detection of genetic defects are reviewed. The general scheme for the utilization of amniotic fluid in prenatal detection of genetic defects is summarized in Fig. 4. A number of cytogenetic and biochemical disorders are capable of detection in utero at the present time. However, until considerably more experience is gained with these techniques, these procedures should be considered experimental in nature. Further investigations are needed to define the normal parameters of amniotic fluid and cultivated amniotic fluid cells in order to maximally utilize this material for the prenatal detection of genetic disorders. © 1969 The C. V. Mosby Company.