SITE-DIRECTED MUTAGENESIS OF HUMAN BETA-ADRENERGIC RECEPTORS - SUBSTITUTION OF ASPARTIC ACID-130 BY ASPARAGINE PRODUCES A RECEPTOR WITH HIGH-AFFINITY AGONIST BINDING THAT IS UNCOUPLED FROM ADENYLATE-CYCLASE

被引:134
作者
FRASER, CM
CHUNG, FZ
WANG, CD
VENTER, JC
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D O I
10.1073/pnas.85.15.5478
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
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页码:5478 / 5482
页数:5
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共 24 条
[11]  
KERLAVAGE AR, 1988, FASEB J, V2, pA599
[12]   MUSCARINIC CHOLINERGIC RECEPTOR STRUCTURE - MOLECULAR BIOLOGICAL SUPPORT FOR SUBTYPES [J].
KERLAVAGE, AR ;
FRASER, CM ;
VENTER, JC .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1987, 8 (11) :426-431
[13]   CLONING, SEQUENCING, AND EXPRESSION OF THE GENE CODING FOR THE HUMAN-PLATELET ALPHA-2-ADRENERGIC RECEPTOR [J].
KOBILKA, BK ;
MATSUI, H ;
KOBILKA, TS ;
YANGFENG, TL ;
FRANCKE, U ;
CARON, MG ;
LEFKOWITZ, RJ ;
REGAN, JW .
SCIENCE, 1987, 238 (4827) :650-656
[14]   PRIMARY STRUCTURE OF PORCINE CARDIAC MUSCARINIC ACETYLCHOLINE-RECEPTOR DEDUCED FROM THE CDNA SEQUENCE [J].
KUBO, T ;
MAEDA, A ;
SUGIMOTO, K ;
AKIBA, I ;
MIKAMI, A ;
TAKAHASHI, H ;
HAGA, T ;
HAGA, K ;
ICHIYAMA, A ;
KANGAWA, K ;
MATSUO, H ;
HIROSE, T ;
NUMA, S .
FEBS LETTERS, 1986, 209 (02) :367-372
[15]   CLONING, SEQUENCING AND EXPRESSION OF COMPLEMENTARY-DNA ENCODING THE MUSCARINIC ACETYLCHOLINE-RECEPTOR [J].
KUBO, T ;
FUKUDA, K ;
MIKAMI, A ;
MAEDA, A ;
TAKAHASHI, H ;
MISHINA, M ;
HAGA, T ;
HAGA, K ;
ICHIYAMA, A ;
KANGAWA, K ;
KOJIMA, M ;
MATSUO, H ;
HIROSE, T ;
NUMA, S .
NATURE, 1986, 323 (6087) :411-416
[16]  
KUNKEL TA, 1985, P NATL ACAD SCI USA, V82, P448
[17]  
LAD PM, 1977, J BIOL CHEM, V252, P5942
[18]   STUDIES ON THYMIDINE KINASE IN CULTURED MOUSE FIBROBLASTS [J].
LITTLEFIELD, JW .
BIOCHIMICA ET BIOPHYSICA ACTA, 1965, 95 (01) :14-+
[19]   ISOLATION, SEQUENCE-ANALYSIS, AND INTRON EXON ARRANGEMENT OF THE GENE ENCODING BOVINE RHODOPSIN [J].
NATHANS, J ;
HOGNESS, DS .
CELL, 1983, 34 (03) :807-814
[20]   PRIMARY STRUCTURE AND BIOCHEMICAL-PROPERTIES OF AN M2 MUSCARINIC RECEPTOR [J].
PERALTA, EG ;
WINSLOW, JW ;
PETERSON, GL ;
SMITH, DH ;
ASHKENAZI, A ;
RAMACHANDRAN, J ;
SCHIMERLIK, MI ;
CAPON, DJ .
SCIENCE, 1987, 236 (4801) :600-605