HYDROLYSIS OF BOUND GTP BY ARF PROTEIN TRIGGERS UNCOATING OF GOLGI-DERIVED COP-COATED VESICLES

被引：215

作者：

TANIGAWA, G

ORCI, L

AMHERDT, M

RAVAZZOLA, M

HELMS, JB

ROTHMAN, JE

机构：

[1] MEM SLOAN KETTERING CANC CTR, CELLULAR BIOCHEM & BIOPHYS PROGRAM, 1275 YORK AVE, NEW YORK, NY 10021 USA

[2] UNIV GENEVA, SCH MED, INST HISTOL & EMBRYOL, CH-1211 GENEVA 4, SWITZERLAND

来源：

JOURNAL OF CELL BIOLOGY | 1993年 / 123卷 / 06期

关键词：

D O I：

10.1083/jcb.123.6.1365

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The cycle of nucleotide exchange and hydrolysis by a small GTP-binding protein, ADP-ribosylation factor (ARF), helps to provide vectoriality to vesicle transport. Coat assembly is triggered when ARF binds GTP, initiating transport vesicle budding, and coat disassembly is triggered when ARF hydrolyzes GTP, allowing the uncoated vesicle to fuse.

引用

收藏

页码：1365 / 1371

页数：7

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