GENETIC DISSECTION OF AUTOIMMUNE TYPE-I DIABETES IN THE BB RAT

被引：226

作者：

JACOB, HJ

PETTERSSON, A

WILSON, D

MAO, Y

LERNMARK, A

LANDER, ES

机构：

[1] MIT,DEPT BIOL,CAMBRIDGE,MA 02139

[2] MIT,CTR GENOME RES,CAMBRIDGE,MA 02139

[3] UNIV WASHINGTON,DEPT MED,SEATTLE,WA 98195

来源：

NATURE GENETICS | 1992年 / 2卷 / 01期

关键词：

D O I：

10.1038/ng0992-56

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The BB rat is among the best models of insulin-dependent diabetes mellitus - with onset and pathogenesis closely resembling the human disease. One unusual feature is a severe T-cell lymphopenia, which appears to be inherited as a recessive trait controlled by a single gene, Lyp. Based on genetic analysis of several crosses, we show that development of diabetes involves at least three genes: Lyp, which is tightly linked to the neuropeptide Y (Npy) gene on chromosome 4, a gene linked to the major histocompatibility complex (MHC) on chromosome 20, and a third unmapped gene for which the Fischer rat strain carries an allele conferring resistance.

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页码：56 / 60

页数：5

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