GENETIC-ANALYSIS OF SUSCEPTIBILITY TO DIABETES-MELLITUS IN F2-HYBRIDS BETWEEN DIABETES-PRONE BB AND VARIOUS MHC-RECOMBINANT CONGENIC RAT STRAINS

被引：10

作者：

GUNTHER, E

KIESEL, U

KOLB, H

KRAWCZAK, M

ROTHERMEL, E

WURST, W

机构：

[1] UNIV DUSSELDORF,DIABET FORSCHUNGSINST,W-4000 DUSSELDORF 1,GERMANY

[2] UNIV GOTTINGEN,HUMAN GENET ABT,W-3400 GOTTINGEN,GERMANY

来源：

JOURNAL OF AUTOIMMUNITY | 1991年 / 4卷 / 03期

关键词：

D O I：

10.1016/0896-8411(91)90165-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The occurrence of diabetes mellitus was analysed in F2 hybrids bred from diabetic BB male rats and females of congenic rat strains carrying different major histocompatibility (RT1) haplotypes on the common LEW strain genetic background. Permissiveness for the disease in BB rats is probably determined by class II genes of the RT1 complex, which are also present in normal rats. Class I and class III genes, notably the Hsp70 genes in the class III region, do not appear to be involved. Among the diabetic F2 hybrids, about 90% are shown by DNA analysis to be homozygous for the class II genes of the permissive RT1 haplotype. The segregation patterns are in accord with the action of two independent recessive genes, one of them being RT1-linked. © 1991.

引用

页码：543 / 551

页数：9

共 14 条

[1] INSULIN-DEPENDENT DIABETES-MELLITUS IS ASSOCIATED WITH GENES THAT MAP TO THE RIGHT OF THE CLASS-I RT1 - A LOCUS OF THE MAJOR HISTOCOMPATIBILITY COMPLEX OF THE RAT [J].