THE MOLECULAR AND GENETIC DISSECTION OF THE RETINOID SIGNALING PATHWAY

被引：81

作者：

CHAMBON, P

机构：

[1] Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire et de Génie Génétique de l'INSERM, Institut de Chimie Biologique, Faculté de Médecine

来源：

GENE | 1993年 / 135卷 / 1-2期

关键词：

VITAMIN-A; CONTROL OF GENE EXPRESSION; EMBRYONIC DEVELOPMENT; RETINOIC ACID RECEPTORS; GENE TARGETING; FUNCTIONAL REDUNDANCY;

D O I：

10.1016/0378-1119(93)90069-F

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Retinoids are derivatives of vitamin A (retinol) that exert a wide variety of profound effects on vertebrate development, cellular differentiation and homeostasis. How these simple molecules can exert such pleiotropic effects has recently been an area of intensive investigation. A complex array of combinatorial effects is beginning to emerge from molecular and genetic studies, which may ultimately account for the pleiotropic effects of retinoids.

引用

页码：223 / 228

页数：6

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