THE MOLECULAR AND GENETIC DISSECTION OF THE RETINOID SIGNALING PATHWAY

被引:81
作者
CHAMBON, P
机构
[1] Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire et de Génie Génétique de l'INSERM, Institut de Chimie Biologique, Faculté de Médecine
关键词
VITAMIN-A; CONTROL OF GENE EXPRESSION; EMBRYONIC DEVELOPMENT; RETINOIC ACID RECEPTORS; GENE TARGETING; FUNCTIONAL REDUNDANCY;
D O I
10.1016/0378-1119(93)90069-F
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Retinoids are derivatives of vitamin A (retinol) that exert a wide variety of profound effects on vertebrate development, cellular differentiation and homeostasis. How these simple molecules can exert such pleiotropic effects has recently been an area of intensive investigation. A complex array of combinatorial effects is beginning to emerge from molecular and genetic studies, which may ultimately account for the pleiotropic effects of retinoids.
引用
收藏
页码:223 / 228
页数:6
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