MURINE ISOFORMS OF RETINOIC ACID RECEPTOR-GAMMA WITH SPECIFIC PATTERNS OF EXPRESSION

被引：345

作者：

KASTNER, P ^{[1
]}

KRUST, A ^{[1
]}

MENDELSOHN, C ^{[1
]}

GARNIER, JM ^{[1
]}

ZELENT, A ^{[1
]}

LEROY, P ^{[1
]}

STAUB, A ^{[1
]}

CHAMBON, P ^{[1
]}

机构：

[1] FAC MED STRASBOURG,CNRS,GENET MOLEC EUCARYOTES LAB,INSERM,UNITE 184,F-67085 STRASBOURG,FRANCE

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1990年 / 87卷 / 07期

关键词：

D O I：

10.1073/pnas.87.7.2700

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have characterized seven murine retinoic acid receptor γ cDNA isoforms (mRAR-γ1 to -γ7) generated by alternative splicing of at least seven exons. These isoforms differ from one another in their 5' untranslated region and in two cases (mRAR-γ1 and -γ2) differ in their N-terminal A region, which is known to be important for differential transactivation by other nuclear receptors. mRAR-γ1 and -γ2, the predominant isoforms, are differentially expressed in adult tissues and during embryogenesis. Most notably, skin contains almost exclusively mRAR-γ1 transcripts. The conservation of the RAR-γ isoforms from mouse to human together with their patterns of expression suggests that they perform specific functions, which may account for the pleiotropic effect of retinoic acid in embryogenesis and development.

引用

页码：2700 / 2704

页数：5

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